Etiological pattern of community-acquired pneumonia related to the new coronavirus infection COVID-19 pandemic in the Saratov Region
- 作者: Portenko S.A.1, Kazakova E.S.1, Naidenova E.V.1, Osina N.A.1, Proskuriakova M.V.1, Katyshev A.D.1, Sharkova E.A.1, Kedrova O.V.1, Chumachkova E.A.1, Shamyunov M.R.2, Kharitonova V.F.3, Gureva L.A.4, Popova N.Y.5, Maksimova L.V.6, Bugorkova S.A.1, Scherbakova S.A.1, Kutyrev V.V.1
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隶属关系:
- Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
- Saratov Polyclinic Hospital No. 5
- Saratov Children’s Infectious Clinical Hospital No. 5
- Saratov Polyclinic No. 2
- City Perinatal Center
- Saratov City Clinical Hospital No. 10
- 期: 卷 12, 编号 1 (2022)
- 页面: 95-104
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/2220-7619/article/view/119038
- DOI: https://doi.org/10.15789/2220-7619-EPO-1747
- ID: 119038
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Community-acquired pneumonia is a polyetiological infectious disease of bacterial or viral nature. In most cases, it is caused by pathogens such as Streptococcus pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, Chlamydophila pneumoniae, Staphylococcus aureus, Legionella spp. However, despite that a wide range of modern diagnostic methods have been introduced into laboratory practice, the etiology of the disease can be determined only in 40–60% of cases. Here, we analyzed the causative agents of community-acquired pneumonia and relevant markers samples of clinical material collected from patients undergoing treatment in the medical facilities of the city of Saratov and the Saratov Region during the period from July to August, 2020, coupled to increase number of cases of new coronavirus infection COVID-19. Clinical material (oropharyngeal swabs, saliva, sputum, blood and blood serum) was obtained from 129 patients and investigated by using microbiological, immunoserological and molecular genetic methods. For this, there were used transport and nutrient media, diagnostic drugs, reagents, discs with antibacterial domestic and foreign drugs registered in the Russian Federation. As a result, 82 (63.6%) patients were found to have markers of the pathogen COVID-19 (viral RNA or specific antibodies of IgM and/or IgG classes), whereas 42% of cases had overlapped RT-PCR and ELISA data. There was a predominance of severe clinical forms of the disease in the group of patients with pneumonia caused by SARS-CoV-2 virus (17.1%), compared with pneumonia of another etiology (12.8%). No marked differences in specific pattern of the accompanying microflora and its sensitivity to antibacterial agents were observed in persons with/without markers of COVID-19. While being examined by bacteriological methods, S. aureus, K. pneumoniae, S. pneumoniae, M. pneumoniae, Acinetobacter spp., both in monoculture and in associations, were isolated from samples of clinical material collected from the majority of patients. In 49.6% of cases, pathogenic microflora, including pathogens causing community-acquired pneumonia, has not been identified, which may be due to the use of antibacterial drugs before the collection of clinical material and treatment applied due to comorbid chronic diseases.
作者简介
S. Portenko
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
编辑信件的主要联系方式.
Email: portenko_sa@microbe.ru
ORCID iD: 0000-0002-8334-9173
Svetlana A. Portenko - PhD (Biology), Head of the Department of Infectious Diseases Diagnostics, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
410005, Saratov, Universitetskaya str., 46.
Phone: +7 927 223-29-92.
俄罗斯联邦E. Kazakova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0002-8424-3864
PhD (Biology), Head Researcher, Department of Infectious Diseases Diagnostics, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦E. Naidenova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: katim2003@mail.ru
ORCID iD: 0000-0001-6474-3696
PhD (Biology), Senior Researcher, Department of Infectious Diseases Diagnostics, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦N. Osina
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: davidova_n_work@mail.ru
ORCID iD: 0000-0003-0954-5683
PhD (Biology), Head of the Microbiology Department, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦M. Proskuriakova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: proma89@mail.ru
ORCID iD: 0000-0002-7171-855X
Researcher, Department of Infectious Diseases Diagnostics, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦A. Katyshev
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0002-8260-4670
Junior Researcher, Microbiology Department, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦E. Sharkova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0001-5807-0368
Junior Researcher, Department of Infectious Diseases Diagnostics, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦O. Kedrova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0001-7400-8599
PhD (Medicine), Academic Secretary, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦E. Chumachkova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
Researcher, Epidemiology Department, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦M. Shamyunov
Saratov Polyclinic Hospital No. 5
Email: gkb5sar@mail.ru
PhD (Medicine), Head Physician, Saratov Polyclinic Hospital No. 5.
Saratov.
俄罗斯联邦V. Kharitonova
Saratov Children’s Infectious Clinical Hospital No. 5
Email: sar5dikb@mail.ru
PhD (Medicine), Head Physician, Saratov Chlidren’s Infectious Clinical Hospital No. 5.
Saratov.
俄罗斯联邦L. Gureva
Saratov Polyclinic No. 2
Email: sekretar@sargp2.ru
Head Physician, Saratov Polyclinic No. 2.
Saratov.
俄罗斯联邦N. Popova
City Perinatal Center
Email: guzpcsar@mail.ru
PhD (Medicine), Head Physician, City Perinatal Center.
Saratov.
俄罗斯联邦L. Maksimova
Saratov City Clinical Hospital No. 10
Email: lpu10gkb@mail.ru
PhD (Medicine), Head Physician, Saratov City Clinical Hospital No. 10.
Saratov.
俄罗斯联邦S. Bugorkova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0001-7548-4845
PhD, MD (Medicine), Head of the Immunology Department, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦S. Scherbakova
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0003-1143-4069
PhD, MD (Biology), Deputy Director for Scientific and Experimental Work, Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
俄罗斯联邦V. Kutyrev
Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor
Email: rusrapi@microbe.ru
ORCID iD: 0000-0003-3788-3452
PhD, MD (Medicine), Professor, RAS Full Member, Director of the Russian Research Anti-Plague Institute “Microbe” of Rospotrebnadzor.
Saratov.
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