Influence of excessive pro-inflammatory immune response on immunological parameters in women with early miscarriages
- 作者: Aleynik V.A.1,2, Zhuraeva M.A.1, Mukhitdinova K.O.1, Babich S.M.1, Negmatshayeva X.N.1
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隶属关系:
- Andijan State Medical Institute
- Academy of Sciences of the Republic of Uzbekistan
- 期: 卷 15, 编号 4 (2025)
- 页面: 673-680
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/2220-7619/article/view/352116
- DOI: https://doi.org/10.15789/2220-7619-IOE-17835
- ID: 352116
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The study results showed that in the early pregnancy (up to 12 weeks) in women with a full-term pregnancy, but suffering from genital infections, changes occur in cellular immune arm. Such alterations affect both innate and adaptive immunity due to activated inflammatory reactions. At the same time, despite detected infection, pregnancy in such women may progression without serious disturbances. However, studies have shown that much more prominent changes in immune system are observed in women with former miscarriages, if they also suffer from genital infections. In women with miscarriages paralleled with genital infections, changes in the immune system are more pronounced that may be accounted for by ongoing immune response hyperreactivity. The latter is referred to an excessive reaction of the immune system to ongoing infection that results in higher inflammation. Such excessive inflammatory processes can cause a disrupted normal mechanisms of pregnancy maintenance, which in turn contributes to increased risk of pregnancy termination, as is observed in miscarriages. In addition, a more pronounced imbalance between pro-inflammatory and anti-inflammatory interleukins is observed in women with miscarriage. Pro-inflammatory interleukins (such as IL-6, IL-1β) potentiate inflammation and may increase the risk of complications during pregnancy, including miscarriage. Anti-inflammatory interleukins, on the other hand, should maintain balance in immune system and counter inflammation, but in case of women with former miscarriage, their activity is insufficient to counteract infection-related inflammatory processes. Thus, the presence of genital infections in women with former miscarriage often leads to excessive immune system activity, which contributes to increased inflammation and disrupted physiological processes that support pregnancy. In such cases, immune response is inadequate and exuberant that may contribute to pregnancy loss.
作者简介
V. Aleynik
Andijan State Medical Institute; Academy of Sciences of the Republic of Uzbekistan
Email: mohigul_azimovna@mail.ru
DSc (Medicine), Professor of the Department of Normal Physiology, Director of the Andijan Branch of the Institute of Immunology and Human Genomics
乌兹别克斯坦, Andijan; AndijanMokhigul Zhuraeva
Andijan State Medical Institute
编辑信件的主要联系方式.
Email: mohigul_azimovna@mail.ru
PhD (Мedicine), Associate Professor, 1st Department of General Practitioners
乌兹别克斯坦, AndijanK. Mukhitdinova
Andijan State Medical Institute
Email: mohigul_azimovna@mail.ru
PhD (Medicine), Assistant Professor, Department of Obstetrics and Gynecology No. 2
乌兹别克斯坦, AndijanS. Babich
Andijan State Medical Institute
Email: mohigul_azimovna@mail.ru
PhD (Мedicine), Associate Professor, Head of the Department of Social Hygiene and Health Management
乌兹别克斯坦, AndijanX. Negmatshayeva
Andijan State Medical Institute
Email: mohigul_azimovna@mail.ru
PhD (Мedicine), Associate Professor, Head of the Department of Obstetrics and Gynecology No. 2
乌兹别克斯坦, Andijan参考
- Areia A.L., Mota-Pinto A. Inflammation and preterm birth: a systematic review. Reprod. Med., 2022, vol. 3, no. 2, pp. 101–111. doi: 10.3390/reprodmed3020009
- Bao J., Zhao C., Wang X., Liu S., Wang L., Zou Y., Liu H. Direct effects of inflammatory cytokines on mouse uterine contraction. Am. J. Reprod. Immunol., 2024, vol. 92, no. 4: e13938. doi: 10.1111/aji.13938
- Daskalakis G., Psarris A., Koutras A., Fasoulakis Z., Prokopakis I., Varthaliti A., Papapanagiotou A. Maternal infection and preterm birth: from molecular basis to clinical implications. Children, 2023, vol. 10, no. 5: 907. doi: 10.3390/children10050907
- Equils O., Kellogg C., McGregor J., Gravett M., Neal-Perry G., Gabay C. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications. Biol. Reprod., 2020, vol. 103, no. 4, pp. 684–694. doi: 10.1093/biolre/ioaa102
- Günther V., Allahqoli L., Deenadayal-Mettler A., Maass N., Mettler L., Gitas G., Alkatout I. Molecular determinants of uterine receptivity: comparison of successful implantation, recurrent miscarriage, and recurrent implantation failure. Int. J. Mol. Sci., 2023, vol. 24, no. 24: 17616. doi: 10.3390/ijms242417616
- Huang Q., Li P., Zheng Z., Sha X., Wang L., Lin B., Liu H. The synergistic effects of prostaglandin and IL-1β on myometrial and cervical stromal cells at the onset of labor. Cytokine, 2025, vol. 190: 156927. doi: 10.1016/j.cyto.2025.156927
- Kumar M., Saadaoui M., Al Khodor S. Infections and pregnancy: effects on maternal and child health. Front. Cell. Infect. Microbiol., 2022, vol. 12: 873253. doi: 10.3389/fcimb.2022.873253
- Löb S., Amann N., Kuhn C., Schmoeckel E., Wöckel A., Kaltofen T., Vilsmaier T. Interleukin-1 beta is significantly upregulated in the decidua of spontaneous and recurrent miscarriage placentas. J. Reprod. Immunol., 2021, vol. 144: 103283. doi: 10.1111/j.1600-0897.1992.tb00737.x
- Meyyazhagan A., KuchiBhotla H., Pappuswamy M., Tsibizova V., Al Qasem M., Di Renzo G.C. Cytokine see-saw across pregnancy, its related complexities and consequences. Int. J. Gynecol. Obstet., 2023, vol. 160, no. 2, pp. 516–525. doi: 10.1002/ijgo.14333
- Nedeva C. Inflammation and cell death of the innate and adaptive immune system during sepsis. Biomolecules, 2021, vol. 11, no. 7: 1011. doi: 10.3390/biom11071011
- Panzer J.J., Romero R., Greenberg J.M., Winters A.D., Galaz J., Gomez-Lopez N., Theis K.R. Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets. BMC Microbiol., 2023, vol. 23, no. 1: 76. doi: 10.1186/s12866-023-02764-6
- Pavlidis I., Stock S.J. Preterm birth therapies to target inflammation. J. Clin. Pharmacol., 2022, vol. 62: S79. doi: 10.1002/jcph.2107
- Socha M.W., Flis W., Pietrus M., Wartęga M., Stankiewicz M. Signaling pathways regulating human cervical ripening in preterm and term delivery. Cells, 2022, vol. 11, no. 22: 3690. doi: 10.3390/cells11223690
- Tantengco O.A.G., Menon R. Breaking down the barrier: the role of cervical infection and inflammation in preterm birth. Front. Glob. Womens Health, 2022, vol. 2: 777643. doi: 10.3389/fgwh.2021.777643
- Vonderlin J., Chavakis T., Sieweke M., Tacke F. The multifaceted roles of macrophages in NAFLD pathogenesis. Cell. Mol. Gastroenterol. Hepatol., 2023, vol. 15, no. 6, pp. 1311–1324. doi: 10.1016/j.jcmgh.2023.03.002
- Yellon S.M. Immunobiology of cervix ripening. Front. Immunol., 2020, vol. 10: 3156. doi: 10.3389/fimmu.2019.03156
- Zeng F., Li Y., Zhang X., Shen L., Zhao X., Beta T., Huang W. Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells. Int. J. Biol. Macromol., 2024, vol. 254: 127700. doi: 10.1016/j.ijbiomac.2023.127700
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