Blood pressure status in patients with metabolic syndrome
- Authors: Sorout J.1, Kacker S.1, Saboo N.1, Kumar M.1
-
Affiliations:
- Rajasthan University of Health Sciences College of Medical Sciences
- Issue: Vol 27, No 4 (2023): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY
- Pages: 419-427
- Section: PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY
- URL: https://journal-vniispk.ru/2313-0245/article/view/319692
- DOI: https://doi.org/10.22363/2313-0245-2023-27-4-419-427
- EDN: https://elibrary.ru/CZEBQX
- ID: 319692
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Abstract
Relevance. Metabolic syndrome (MetS) is existence of many abnormalities, such as abdominal obesity, hypertension, dyslipidemia, and glucose intolerance. The occurrence of MetS in hypertensive people is linked to poorly managed hypertension. One of the parameters for the diagnosis of the syndrome is the presence of increased blood pressure; nevertheless, research shows that MetS patients are likely to experience hypertension often. Materials and Methods. 300 metabolic subjects were selected from the medicine OPD as study participants based on the joint interim statement’s 2009 definition of the metabolic syndrome. They were divided into three groups (normotensive, pre-hypertensive, and hypertensive) based on blood pressure readings that met the American Heart Association’s (AHA) Asian blood pressure criteria. The following parameters were recorded for data collection: anthropometric (Weight, Height, Body Mass Index Waist Hip Ratio), Blood pressure, biochemical (Fasting blood glucose, Lipid profile parameters). Results and Discussion. According to the resting blood pressure readings, out of 300 metabolic syndrome participants, 37 were normotensive [male (40.54 %); female (59.45 %)], 115 were pre-hypertensive [male (58.26 %); female (41.74 %), and 148 were hypertensive [male (52.7 %); female (47.3 %)]. In several parameters, there was no such significant difference between male and female participants across all groups. However, the levels of blood total cholesterol, triglycerides, and low-density lipoprotein were considerably greater in hypertensive and pre-hypertensive metabolic participants than in normotensive subjects, while the levels of high-density lipoprotein were lower. Conclusion. Study findings suggest, hypertension and pre-hypertension were more prevalent in the group with metabolic syndrome. Additionally, hypertensives have a higher chance of manifesting dyslipidemia.
About the authors
Jitender Sorout
Rajasthan University of Health Sciences College of Medical Sciences
Email: nehasaboo8@gmail.com
ORCID iD: 0000-0002-1510-0982
Jaipur, Rajasthan, India
Sudhanshu Kacker
Rajasthan University of Health Sciences College of Medical Sciences
Email: nehasaboo8@gmail.com
ORCID iD: 0000-0001-8947-2036
Jaipur, Rajasthan, India
Neha Saboo
Rajasthan University of Health Sciences College of Medical Sciences
Author for correspondence.
Email: nehasaboo8@gmail.com
ORCID iD: 0000-0002-3874-1459
Jaipur, Rajasthan, India
Munesh Kumar
Rajasthan University of Health Sciences College of Medical Sciences
Email: nehasaboo8@gmail.com
ORCID iD: 0009-0003-2499-6500
Jaipur, Rajasthan, India
References
- Mohanan PP. Metabolic syndrome in Indian population: public health implication. Hypertens J. 2016;2:1-6.
- Deedwania PC, Gupta R. Management issues in the metabolic syndrome. J Assoc Physicians India. 2006; 54: 797-810.
- Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415-28. doi: 10.1016/S0140-6736(05)66378-7
- van der Pal KC, Koopman ADM, Lakerveld J, van der Heijden AA, Elders PJ, Beulens JW, Rutters F. The association between multiple sleep-related characteristics and the metabolic syndrome in the general population: the New Hoorn study. Sleep Med. 2018;52:51-57. doi: 10.1016/j.sleep.2018.07.022
- Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-52. doi: 10.1161/01.HYP.0000107251.49515.c2
- Arcucci O, de Simone G, Izzo R, Rozza F, Chinali M, Rao MA, Bodenizza C, De Luca N, Trimarco B. Association of suboptimal blood pressure control with body size and metabolic abnormalities. J Hypertens. 2007;25(11):2296-300. doi: 10.1097/ HJH.0b013e3282e9a9e4
- Chimonas T, Karagiannis A, Athyros VG, Achimastos A, Elisaf M, Panagiotakos DB. Assessing The Treatment Effect in Metabolic Syndrome without Perceptible diabeTes (ATTEMPT) Collaborative Group. Blood pressure levels constitute the most important determinant of the metabolic syndrome in a Mediterranean population: a discrimination analysis. Metab Syndr Relat Disord. 2010;8(6):523-9. doi: 10.1089/met.2010.0023
- Mancia G, Bousquet P, Elghozi JL, Esler M, Grassi G, Julius S, Reid J, Van Zwieten PA. The sympathetic nervous system and the metabolic syndrome. J Hypertens. 2007;25(5):909-20. doi: 10.1097/ HJH.0b013e328048d004
- Tziomalos K, Athyros VG, Karagiannis A, Mikhailidis DP. Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management. NutrMetab Cardiovasc Dis. 2010;20:140-46. doi: 10.1016/j.numecd.2009.08.006
- Yadav R, Yadav RK, Khadgawat R, Pandey RM, Upadhyay AD, Mehta N. Randomized Controlled Trial of A 12-Week Yoga-Based (Including Diet) Lifestyle vs. Dietary Intervention on Cardio-Metabolic Risk Factors and Continuous Risk Score in Indian Adults with Metabolic Syndrome. Behav Med. 2020;46(1):9-20. doi: 10.1080/08964289.2018.1538098
- National Health and Nutrition Examination Survey (NHANES)- Anthropometry Procedures Manual, January 2007. https://wwwn.cdc.gov/nchs/data/nhanes/20152016/manuals/2016_Anthropometry_Procedures_Manual.pdf. [Acessed on 13 June 2023]
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114(2 Suppl 4th Report):555-76
- Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969;22(2):158-61. doi: 10.1136/jcp.22.2.158
- Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20(4):470-5
- Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982;28(10):2077-80.
- Huang Y, Cai X, Liu C, Zhu D, Hua J, Hu Y, Peng J, Xu D. Prehypertension and the risk of coronary heart disease in Asian and Western populations: a meta-analysis. J Am Heart Assoc. 2015;4(2): e001519. doi: 10.1161/JAHA.114.001519
- Mohan V, Rao GHR. Type 2 Diabetes in South Asains. 1st ed. New Delhi: South Asian Society on Atherosclerosis and Thrombosis. 2007. New Delhi. India. 435 p.
- Misra A, Khurana L. The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metab Syndr Relat Disord. 2009;7(6):497-514. doi: 10.1089/met.2009.0024
- WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157-63. doi: 10.1016/ S0140-6736(03)15268-3
- Lean ME, Han TS, Morrison CE. Waist circumference as a measure for indicating need for weight management. BMJ. 1995;311(6998):158-61. doi: 10.1136/bmj.311.6998.158
- Lv Y, Yao Y, Ye J. Association of Blood Pressure with Fasting Blood Glucose Levels in Northeast China: A Cross-Sectional Study. Sci Rep. 2018; (8):7917. doi: 10.1038/s41598-018-26323-6
- Jia G, DeMarco VG, Sowers JR. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144-53. doi: 10.1038/nrendo.2015.216
- NIH ATP 3 Guidelines and overview of antilipid medications: http://www.nhlbi.nih.gov/health-pro/guidelines/current/cholesterol guidelines/quick-desk-reference-html [Acessed on 13 June 2023].
- Choudhury KN, Mainuddin AK, Wahiduzzaman M, Islam SM. Serum lipid profile and its association with hypertension in Bangladesh. Vasc Health Risk Manag. 2014;10:327-32. doi: 10.2147/VHRM.S61019
- Lewis GF, Uffelman KD, Szeto LW, Steiner G. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes. 1993;42(6):833-42. doi: 10.2337/diab.42.6.833
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