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Vol 15, No 2 (2015)
- Year: 2015
- Articles: 12
- URL: https://journal-vniispk.ru/MAJ/issue/view/605
Articles
THE FIRST HONORARY MEMBER OF THE IMPERIAL INSTITUTEOF EXPERIMENTAL MEDICINE
Abstract
In 2015, 170 years since the birth of Princess Yevgeniya Maksimilianovna Oldenburgskaya (1845-1925) passed. She may be safely characterized as the first business-woman of the Imperial family of the Romanovs. Yevgeniya who was born and grown up in Saint-Petersburg imbibed its «panhuman soul capable of responsiveness to the whole world». Having married and having become the princess, she not only took active part in developing the of policy of national education of Russia, but also played a noticeable role in managing many medical facilities and the first Russian medical research institute by regularly performing the duties of its Trustee.
Medical academic journal. 2015;15(2):7-14
7-14
GLUTAMINE AND ITS DERIVATIVES FOR CORRECTION OF METABOLICDISORDERS IN HIV PATIENTS
Abstract
Glutamine content is decreased in HIV patients because of its increased metabolizing by cells of the immune system. The progression of HIV infection is associated with body weight loss in patients. This loss is aggravated by opportunistic infections associated with fever, anorexia, diarrhea and malabsorption and correlates with decreased glutamine content. Glutamine deficiency facilitates the initial immunity-mediated multiplication of HIV and may lead to perpetual (chronic) activation of the immune system even after the complete suppression of HIV. Treating HIV patients with glutamine preparations results in improved cenesthesia, decreased neurotoxic phenomena, and increased motor activity.
Medical academic journal. 2015;15(2):15-27
15-27
MARINESCO BODIES: INTRANUCLEAR INCLUSION-BODIESOF DOPAMINERGIC NEURONS
Abstract
Available data are reviewed on the intranuclear inclusions known as Marinesco bodies in nerve cells. These structures were described for the first time in 1902 in the pigmented areas of human brain (substantia nigra and locus coeruleus), mainly in the melanin-containing neurons. Their sizes correspond roughly to those of nucleoli. One nucleus may contain several Marinesco bodies. Immunohistochemistry showed thate Marinesco bodies comprise ubiquitin and some other proteins of the ubiquitin-proteasome system as well as optineurin and valosin-containing protein, but not proteins associated with the development of certain neurodegenerative diseases, such as в-amyloid, а-synuclein, tau-protein, and the prion protein PrP. A tendency to an increase in the number of Marinesco bodies with increasing age was found, but no correlation with any brain pathology was revealed.
Medical academic journal. 2015;15(2):28-34
28-34
BIOLOGICAL AND PROTECTIVE PRORERTIES OF THE SERUMANTIBODIES DIRECTED AGAINST INFLUENZA VIRUS NEURAMINIDASE
Abstract
This lecture highlights issues of the immunogenicity and protective value of the second antigenic component of influenza virus - neuraminidase (NA), and summarizes the results of a method development for evaluation anti-NA serum antibodies directed against influenza viruses of pandemic and potentially pandemic subtypes. This technique can be used in the estimation of population immunity against the influenza viruses, as well as the study of the immunogenicity of live influenza vaccines (LAIV) as one of the criteria of vaccine registration.
Medical academic journal. 2015;15(2):35-44
35-44
SPECIFIC FEATURES OF TGF-p 1 EXPRESSION IN THE LEFT AND RIGHT HEART SEGMENTS DURING EXPERIMENTAL CHRONIC ADRENERGICAND CHOLINERGIC STRESS
Abstract
Studied was the expression of transforming growth factor P1 in the myocardium of the left and right heart segments during experimental chronic adrenergic stress (CAS) and chronic cholinergic stress (CCS) in Wistar rats. TGF-P1 expression during CAS was significantly elevated in the right atrium (RA) in comparison with the left atrium (LA). On the contrary, endothelial TGF-P1 expression in the right atrium during CCS was significantly lower than in the left atrium. No significant differences in TGF-P1 expression were found between the left ventricle (LV) and right ventricle (RV) in the models, CAS and CC; however, there was a trend to a higher expression of TGF-P1 in RV during CAS. The results suggest that there are no significant difference in TGF-P1 expression between heart ventricles; however, during CAS, TGF-P1 expression is significantly higher in right atrium compared with the right ventricle, and a similar trend is observed during CCS.
These findings demostratea «mosaic» pattern of TGF-P1 expression in heart atria and ventricles during chronic stress, which can cause differences in the remodeling of the various parts of the heart.
Medical academic journal. 2015;15(2):45-49
45-49
THE EFFECT OF INTRASTRIATAL ZINC ACETATEC INJECTIONS ONNORMALAND PATHOLOGICAL LOCOMOTOR BEHAVIOR IN RATS
Abstract
Free locomotor activity and conditional avoidance behavior in a «shuttle box» upon multiple injections of zincacetate (1 mg) into rats rostral neostriatum were studied. Zinc acetate was injected daily for two weeks separately or in combination with the GABA-A receptor antagonist picrotoxin (2 mg). Zinc acetate did not s ignificantly influence conditional avoidance reflexes, but increased the- free locomotor activity and motor stereotypy in the rats. Injected with picrotoxin, it lowered the hyperkinetic effect of picrotoxin within the first few days of microinjections, but potentiated its negative effecton conditional avoidance reflexes. In the subsequent days, the effects zincacetatechanged: the reproducibility of the hyperkinetic effects of picrotoxin increased, and the conditional avoidance behavior recovered. The results suggest that zinc, Ittproduces combined and multiple effects on ion homeostasis and brain neurons and synapses. Dependingt on the dosage, duration and regimen of injections, zinc can affected various brain systems and produce different, often contradictory, behavioral changes.
Medical academic journal. 2015;15(2):50-54
50-54
THE OXIDATIVE STATUS OF BLOOD AND TISSUES IN INFLAMMATORY AND DEGENERATIVE DAMAGE TO THE SMOOTH PARODENTIUM TISSUE IN RATS AFTER USING OF TOOTH PASTES AND THEIR SEPARATE COMPONENTS
Abstract
A rat model of inflammatory and degenerative damage to the smooth parodentium tissue, which is produced by administering 2% aqueous formaldehyde into the smooth parodentium, is described. The oxidative status of rats, including lipid peroxidation and antioxidant system parameters, was assessed because of its high sensitivity to inflammation. Malondialdehyde and diene conjugates levels were 2- to 3-fold higher in blood serum and parodentium tissue 7 days after the onset of inflammation. Reduced glutathion level and superoxide dismutase activity were somewhat more sensitive than the parameters of lipid peroxidation: blood serum reduced glutathione decreased from 2,02±0,09 to 0,88±0,21 pM/mL, and superoxide dismutase activity decreased from 0,78±0,10 to 0,28±0,04 unit/mg protein, that is, decreased 2,5 to 3 times. Similar changes were observed in the smooth parodentium: reduced glutathione decreased 2,1-fold, and superoxide dismutase activity decreased 7-fold. The toothpastes Lesmin-Dent,Clamin-Dent and Zhemchug (in the order of descending activity) attenuated or abolished the signs of inflammatory and degenerative damages to the smoothparodentium tissue in rats, as assessed by lipid peroxidation and antioxidant defense parameters. The antihypoxic drugs Midalon, Elam-A, and Elam-M (in the order of descending activity) after 7 days of oral administration attenuated the signs of
inflammatory and degenerative damage to the smooth parodentium more than the toothpastes did. Therefore, the curative and preventive effects of toothpastes and dental drugs may be assessed using the above model of inflammation.
Medical academic journal. 2015;15(2):55-61
55-61
MICROCIRCULATORY DISORDERS OF THE LIVER FOUND WITH POLYHEPATOGRAPHY IN PATIENTS WITH ISCHEMIC HEART DISEASEAND HYPERTENSION
Abstract
The article presents the results of a study of three groups of patients (n=90): Group I: patients with stable ischemic heart disease combined with hypertension; Group II - patients with Stage II essential hypertension without ischemic heart disease; Group III - healthy controls people. Microcirculation in the liver was assessed with polyhepatography in all patients. Significant differences between the groups were found in the locations of intrahepatic blood flow disturbances. This findingmay be useful in differentiatial treatment of these diseases.
Medical academic journal. 2015;15(2):62-68
62-68
PREVENTION OF SKIN GRAFTS LYSIS UPON THE SURGICAL TREATMENTOF DEEP BURNS
Abstract
The article presents a study of immunological markers that predict the rejection of skin grafts in patients with deep burns. We used the immunological indicators of autosensitization to destructed elements of the skin, namely, serum antinuclear antibodies and antibodies against extractable antigens. Of two groups, which comprised 20 miners injured by methane-coal mixture explosions in deep mines of Donbass, in the group where these indicators were used to predict autosensitization, the rate of autologous skin grafts per patient was 1.72 times lower, and the time of inpatient treatment was 17 days shorter.
Medical academic journal. 2015;15(2):69-72
69-72
ON MOLECULAR EPIDEMIOLOGY OF HEPATITIS D IN KYRGYZSTAN
Abstract
HBV and HDV co-infection or superinfectionis significantly associated with markedly more severe liver disease compared with that upon a mono-infection with either of the viruses. This rises the attention of epidemiologists to the sources and transmission routes of hepatitis D, especially in hyper-endemic regions and countries. In 30 patient plasma samples collectedin Kyrgyzstan, genotype IHDV was found. The high variability of viral genome region encoding delta-antigen may be an indication of numerous independent entries of different HDV strains into the the country and, also, of a high rate of evolution of the virus in a geographically isolated region. The high similarity of some isolates with strains specific for neighboring countries endemic for HDV, as well as the close clustering of other isolates confirm bothhypotheses. It is important to identification propagation characteristics and the role of endemicity in the circulation of HDV genotypes of D is great importance.
Medical academic journal. 2015;15(2):73-78
73-78
THE STRUCTURE OF INSTITUTE OF EXPERIMENTAL MEDICINE (LENINGRAD BRANCH OF ALL-UNION INSTITUTE OF EXPERIMENTAL MEDICINE)DURING THE GREAT PATRIOTIC WAR (ARCHIVAL MATERIALS)
Abstract
The present article is dedicated to the 70th anniversary of the victory of our country in the Great Patriotic War. It contains previously unpublished data on the structure of Institute of Experimental Medicine and information about the staff of the Institute before the war (the end of 1940), during the siege of Leningrad, and in the course of organization of the restoration of full-scale activities of the scientific departments of the Institute (1944). The list of names of scientists working at the Institute during 1942-1944 is presented based on documents filed in the archive of Institute of Experimental Medicine.
Medical academic journal. 2015;15(2):79-86
79-86
PRAVILA OFORMLENIYa STATEY
Medical academic journal. 2015;15(2):88-
88-