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Post a Comment Pharmacokinetic peculiarities of intravenous and oral ciprofloxacin administration in preoperative prophylaxis in patients with benign prostatic hyperplasia
- Authors: Sosin I.V.1, Rafalskiy V.V.2, Shabanov P.D.3
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Affiliations:
- Smolensk regional clinical hospital
- Smolensk State Medical Academy
- Kirov Military Medical Academy
- Issue: Vol 12, No 4 (2014)
- Pages: 64-66
- Section: Articles
- URL: https://journal-vniispk.ru/RCF/article/view/780
- DOI: https://doi.org/10.17816/RCF12464-66
- ID: 780
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Abstract
The study of population pharmacokinetics of ciprofloxacin at various ways of administration helps to found that the once usage of 500 mg ciprofloxacin orally 90-120 min before the surgery as preoperative antibiotic prophylaxis with transurethral resection of the prostate gland creates a significantly higher concentration of the drug in blood, urine and prostate parenchyma compared to intravenously administration of 400 mg ciprofloxacin 30-60 min before operation. Thus, the data obtained explain the higher efficacy of oral administration of ciprofloxacin as preoperative antibiotic prophylaxis in patients undergoing transurethral resection of the prostate.
About the authors
Igor Vladimirovich Sosin
Smolensk regional clinical hospital
Email: sosin1979@yandex.ru
urologist
Vladimir Vitalevich Rafalskiy
Smolensk State Medical Academy
Email: v.rafalskiy@mail.ru
Dr. Med. Sci. (Pharmacology), Professor, Dept. of Administration and Economic of Pharmacy
Petr Dmitriyevich Shabanov
Kirov Military Medical Academy
Email: pdshabanov@mail.ru
Doct. of Med. Sci. (Pharmacology), Professor and Head, Dept. of Pharmacology
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