电邮这篇文章 Comparison of the state of brain metabolism and psycho emotional disorders in patients with postmastectomy syndrome
- 作者: Makhanova A.M.1, Pospelova M.L.1, Ryzhkova D.V.1, Alexeeva T.M.1, Fionik O.V.1, Krasnikova V.V.1, Tonyan S.N.1, Nikolaeva A.E.1, Bukkieva T.A.1, Mokin E.A.1, Voynov M.S.1, Laptev M.I.1, Vyalykh E.E.1
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隶属关系:
- Personalized Medicine Centre, Almazov National Medical Research Centre
- 期: 卷 41, 编号 4 (2022)
- 页面: 399-406
- 栏目: Original articles
- URL: https://journal-vniispk.ru/RMMArep/article/view/111887
- DOI: https://doi.org/10.17816/rmmar111887
- ID: 111887
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详细
BACKGROUND: The most common consequence of radical treatment of breast cancer is postmastectomy syndrome — a complex of changes in the lymphocirculatory system, central and peripheral nervous system, skeletal and muscular apparatus, that significantly reduce the quality of life and working capacity of women. In recent years, special attention has been paid to the study of psycho emotional disorders in this group of patients. A promising method for preclinical diagnosis of anxiety and depressive disorders in patients with postmastectomy syndrome may be positron emission computed tomography with fluorine-18 labeled glucose — 2(18F)-fluoro-2-deoxy-D-glucose, which makes it possible to deduce typical patterns of changes in glucose metabolism in cerebral structures in various depressive and anxiety states.
AIM: The purpose of this study is to study the relationship between brain metabolism and psycho emotional status in patients with postmastectomy syndrome.
MATERIALS AND METHODS: In our work, the sample consisted of 28 patients who underwent radical treatment for breast cancer, who underwent an assessment of the psycho-emotional state using the State-Trait Anxiety Inventory and Zung scales for self-assessment of depression. Positron emission tomography was also performed with 18-fluorodeoxyglucose.
RESULTS: The study revealed that 71% of patients showed an increased level of anxiety, 64% showed signs of depression. Positron emission tomography data revealed the following areas of hypometabolism in patients with anxiety-depressive disorders: parietal cortex, inferior parietal lobule, precuneus, superior temporal gyrus, prefrontal cortex, posterior cingulate cortex.
CONCLUSION: Thus, typical zones of changes in glucose metabolism in patients with psycho emotional disorders have been identified, which makes it possible to improve the accuracy of diagnosing these conditions, as well as to develop the most effective ways to prevent and treat them.
作者简介
Albina Makhanova
Personalized Medicine Centre, Almazov National Medical Research Centre
编辑信件的主要联系方式.
Email: a.mahanova.a@mail.ru
ORCID iD: 0000-0003-3188-1886
SPIN 代码: 5451-6934
Scopus 作者 ID: 57423725500
Researcher ID: GRX-3020-2022
M.D., junior research fellow
俄罗斯联邦, Saint PetersburgMaria Pospelova
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: pospelovaml@mail.ru
ORCID iD: 0000-0003-3553-6537
SPIN 代码: 1835-0074
Scopus 作者 ID: 57202465838
Researcher ID: ABI-4863-2020
M.D., D.Sc (Medicine), Professor
俄罗斯联邦, Saint PetersburgDaria Ryzhkova
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: d_ryjkova@mail.ru
ORCID iD: 0000-0002-7086-9153
SPIN 代码: 7567-6920
Scopus 作者 ID: 6602541507
Researcher ID: C-5262-2018
M.D., D.Sc (Medicine), Professor
俄罗斯联邦, Saint PetersburgTatiana Alexeeva
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: atmspb@mail.ru
ORCID iD: 0000-0002-4441-1165
SPIN 代码: 3219-2846
Scopus 作者 ID: 57200808136
Researcher ID: S-88062017
M.D., D.Sc (Medicine), Professor
俄罗斯联邦, Saint PetersburgOlga Fionik
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: fvolga@mail.ru
ORCID iD: 0000-0002-9730-1226
SPIN 代码: 8133-4875
Scopus 作者 ID: 6503989626
M.D., D.Sc (Medicine), Professor
俄罗斯联邦, Saint PetersburgVarvara Krasnikova
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: samvelium@gmail.com
ORCID iD: 0000-0002-3261-8812
SPIN 代码: 2870-8678
Scopus 作者 ID: 57189012524
Researcher ID: ABI-5158-2020
M.D., junior research fellow
俄罗斯联邦, Saint PetersburgSamwel Tonyan
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: samvelium@gmail.com
ORCID iD: 0000-0002-7475-1873
Researcher ID: GRX-5113-2022
M.D., Postgraduate Student, Neurology and Psychiatry Department
俄罗斯联邦, Saint PetersburgAlexandra Nikolaeva
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: shura.nicolaeva@yandex.ru
ORCID iD: 0000-0002-4550-1883
SPIN 代码: 4103-9192
Researcher ID: GRX-9922-2022
M.D., laboratory assistant-researcher
Saint PetersburgTatyana Bukkieva
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: tanya-book25@mail.ru
ORCID iD: 0000-0002-6779-0241
SPIN 代码: 5833-3305
Scopus 作者 ID: 57210339683
Researcher ID: ABI-5143-2020
M.D., Postgraduate Student 3 years of the Radiation Diagnostics Dep.
Saint PetersburgEgor Mokin
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: mokinegor49@gmail.com
ORCID iD: 0000-0002-8080-9955
SPIN 代码: 6105-7916
Scopus 作者 ID: 57207300715
Researcher ID: GRX-6715-2022
M.D., intern at the Neurology and Psychiatry Department
俄罗斯联邦, Saint PetersburgMark Voynov
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: voynov.ms@gmail.com
ORCID iD: 0000-0002-5765-4289
Researcher ID: GRS-9470-2022
M.D., 5th year student
俄罗斯联邦, Saint PetersburgMatvey Laptev
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: matveylaptev2002@gmail.com
ORCID iD: 0000-0002-6749-4661
Researcher ID: GRX-0569-2022
M.D., 3rd year student
俄罗斯联邦, Saint PetersburgEkaterina Vyalykh
Personalized Medicine Centre, Almazov National Medical Research Centre
Email: katya071201@gmail.com
ORCID iD: 0000-0002-8185-9807
Researcher ID: GRX-2816-2022
M.D., 4th year student
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