DEVELOPMENT OF AN ANTISEPTIC PRODUCT BASED ON CHLORGEXIDINE BIGLUCONATE

In recent years, in connection with the increase in the requirements for the work of healthcare institutions and high-tech industries, special attention has been paid to ensuring sterility. The creation, improvement, and proper use of antiseptics and disinfectants remains one of the most important aspects of safe operation. By presidential decree of May 7, 2018 No. 204 «About national goals and strategic objectives of the development of the Russian Federation for the period until 2024», the Government of the Russian Federation was instructed to develop, among others, a national program for the development of health care. As part of the implementation of the provisions of this decree, work is underway on the Development Strategy of the pharmaceutical industry of the Russian Federation for the period until 2030, which focuses on import substitution. In this regard, an attempt was made to create a domestic disinfectant. The article presents the result of a multi-stage development of the composition of a skin antiseptic based on chlorhexidine digluconate. First of all, an analysis of the regulatory framework related to the use of antiseptic and sterilizing agents, a study of the domestic market of skin antiseptics was performed and thus the relevance of this study was shown. In the second stage, the solution technology of the future agent was selected taking into account the effectiveness, safety, and compatibility of substances, economic benefits, and simplicity of production, and the organoleptic properties of the experimental samples were taken into account. At the final stage, quality control was carried out by physicochemical and microbiological methods, which included qualitative, quantitative determination and verification of the resistance of organisms to the solution. At the end of the work, a conclusion was drawn about the possibility of using the drug in hospitals, and other conditions requiring sterility.

skin antiseptics, antiseptic market, hand treatment, hygiene of medical personnel, chlorhexidine bigluconate, solution technology, microbiological purity, sterility