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发表评论 Cerebral damage pathogeny peculiarities in local and globalcerebral perfusion impairment models in rats
- 作者: Zelenenko M.A.1, Pechatnikova V.A.2, Zaplutanov V.A.1, Tsygan N.V.3, Verlov N.A.2, Khotin M.G.4, Vasiliev A.G.5, Trashkov A.P.2
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隶属关系:
- I.M. Sechenov institute of evolutionary physiology and biochemistry, Russian academy of sciences
- Petersburg Nuclear Physics Institute named by B.P. Konstantinov
- Military Medical Academy n.a. S.M. Kirov
- Institute of Cytology, Russian academy of sciences
- St. Petersburg State Pediatric Medical University
- 期: 卷 8, 编号 6 (2017)
- 页面: 62-71
- 栏目: Articles
- URL: https://journal-vniispk.ru/pediatr/article/view/7878
- DOI: https://doi.org/10.17816/PED8662-71
- ID: 7878
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A complex study of clinical and laboratory pathogenic features of cerebrovascular disease has been performed in rats using two experimental models: local ischemia with cerebral infarction and global ischemia caused by acute or chronic impairment of cerebral circulation without verified site of brain damage. A pronounced difference has been demonstrated between the two studied models of cerebral impairment. The development of brain damage site constituting 20-30% of the total cortex of the impaired hemisphere was demonstrated to be accompanied by a considerable increase of basic nervous tissue damage markers (neuron-specific enolase, S100β-protein), development of endothelial dysfunction and hemostasiological disturbances. Irreparable cerebral circulation impairment by ligation of carotid arteries was followed by considerably lower lethality in the experimental animals, neurospecific markers’ moderate dynamics but however side by side with pronounced and inadequately compensated manifestations in the hemostasis system and vascular endothelium caused by brain hypoxia.
作者简介
Maria Zelenenko
I.M. Sechenov institute of evolutionary physiology and biochemistry, Russian academy of sciences
编辑信件的主要联系方式.
Email: magu56110@gmail.com
MD, researcher, Experimental Pharmacology Dept
俄罗斯联邦, Saint PetersburgValeria Pechatnikova
Petersburg Nuclear Physics Institute named by B.P. Konstantinov
Email: floluttrell@gmail.com
researcher Radiopharmpreparations Test Center
俄罗斯联邦, GatchinaVassiliy Zaplutanov
I.M. Sechenov institute of evolutionary physiology and biochemistry, Russian academy of sciences
Email: vasiliy@zaplutanov.ru
MD, researcher, Experimental Pharmacology Deptartment
俄罗斯联邦, Saint PetersburgNikolay Tsygan
Military Medical Academy n.a. S.M. Kirov
Email: 77tn77@gmail.com
MD, PhD, Dr.Med. Sci., Assoc. Prof. Neurology Deptartment
俄罗斯联邦, Saint PetersburgNikolay Verlov
Petersburg Nuclear Physics Institute named by B.P. Konstantinov
Email: virlov@gmail.com
PhD, Senior researcher Radiopharmpreparations Test Center
俄罗斯联邦, GatchinaMichael Khotin
Institute of Cytology, Russian academy of sciences
Email: h_mg@mail.ru
PhD, Heaqd, Lab. Of Biomedical Technologies and Tests
俄罗斯联邦, Saint PetersburgAndrei Vasiliev
St. Petersburg State Pediatric Medical University
Email: avas7@mail.ru
MD, PhD, Dr. Med. Sci., Head of Pathophysiology Deptartment
俄罗斯联邦, Saint PetersburgAlexander Trashkov
Petersburg Nuclear Physics Institute named by B.P. Konstantinov
Email: alexandr.trashkov@gmail.com
MD, PhD, Head Radiopharmpreparations Test Center
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