Clinical and immunological phenotypes of the chronic rhinosinusitis with polyposis
- Authors: Mokronosova MА1, Ruyan J.S1, Mustafaeva DM1, Smolnikova EV1, Protasov PG1
-
Affiliations:
- Federal ENT Centre
- Issue: Vol 7, No 4 (2010)
- Pages: 3-9
- Section: Articles
- URL: https://journal-vniispk.ru/raj/article/view/121200
- DOI: https://doi.org/10.36691/RJA859
- ID: 121200
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Abstract
The pathogenesis of chronic rhinosinusitis with nasal polyposis is still unknown.
The aim. To estimate IgE-antibodies to staphylococcal enterotoxines and fungal allergens mix in nasal polyps'supernatant and sera
of three phenotypes of chronic rhinosinusitis.
Patients and methods. Chronic rhinosinusitis with nasal polyposis with aspirin intolerance - 12 patients, chronic rhinosinusitis
with nasal polyposis with atopy - 15 patients, chronic rhinosinusitis with nasal polyposis without atopy and aspirin intolerance -
10 patients, and 6 healthy persons were observed. The levels of ECP, tryptase, total IgE, IgE-antibodies to staphylococcal enterotoxines,
fungal mix in sera and supernatant of polyp's tissue were detected by ImmunoCaplOO (Phadia AB).
Results. The incidence of IgE-antibodies to staphylococcal enterotoxines makes up 12,6% in the sera of all patients, and 30% in polyp's
tissue in nonatopic patients and in none of atopics. The local production of IgE-antibodies to fungi in polyp's tissue was high and
revealed in 30-73% of all patients (more often in patients with aspirin intolerance - in 73% of cases). There was no dependence
between the incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in the sera and polyps and the chronic
rhinosinusitis with nasal polyposis.
Conclusion. The incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in polyp's tissue is higher than in
sera as in atopic as in nonatopic pts. There were IgE-antibodies to fungi in polyp's tissue in 73% of patients with aspirin intolerance. The
presence of IgE-antibodies did not influence on the level of ECP and severity of chronic rhinosinusitis with nasal polyposis .
The aim. To estimate IgE-antibodies to staphylococcal enterotoxines and fungal allergens mix in nasal polyps'supernatant and sera
of three phenotypes of chronic rhinosinusitis.
Patients and methods. Chronic rhinosinusitis with nasal polyposis with aspirin intolerance - 12 patients, chronic rhinosinusitis
with nasal polyposis with atopy - 15 patients, chronic rhinosinusitis with nasal polyposis without atopy and aspirin intolerance -
10 patients, and 6 healthy persons were observed. The levels of ECP, tryptase, total IgE, IgE-antibodies to staphylococcal enterotoxines,
fungal mix in sera and supernatant of polyp's tissue were detected by ImmunoCaplOO (Phadia AB).
Results. The incidence of IgE-antibodies to staphylococcal enterotoxines makes up 12,6% in the sera of all patients, and 30% in polyp's
tissue in nonatopic patients and in none of atopics. The local production of IgE-antibodies to fungi in polyp's tissue was high and
revealed in 30-73% of all patients (more often in patients with aspirin intolerance - in 73% of cases). There was no dependence
between the incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in the sera and polyps and the chronic
rhinosinusitis with nasal polyposis.
Conclusion. The incidence of IgE-antibodies to staphylococcal enterotoxines, fungal allergens mix in polyp's tissue is higher than in
sera as in atopic as in nonatopic pts. There were IgE-antibodies to fungi in polyp's tissue in 73% of patients with aspirin intolerance. The
presence of IgE-antibodies did not influence on the level of ECP and severity of chronic rhinosinusitis with nasal polyposis .
About the authors
M А Mokronosova
Federal ENT Centre
Email: mmokronosova@mail.ru
Federal ENT Centre
Ju S Ruyan
Federal ENT CentreFederal ENT Centre
D M Mustafaeva
Federal ENT CentreFederal ENT Centre
E V Smolnikova
Federal ENT CentreFederal ENT Centre
P G Protasov
Federal ENT CentreFederal ENT Centre
References
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