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发表评论 剖宫产术后子宫内膜炎的抗菌治疗：给药方案的优化
- 作者: Korobkov N.A.1, Bakulina N.V.1, Repina M.A.1
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隶属关系:
- North-Western State Medical University named after I.I. Mechnikov
- 期: 卷 12, 编号 4 (2020)
- 页面: 67-72
- 栏目: Original research
- URL: https://journal-vniispk.ru/vszgmu/article/view/50864
- DOI: https://doi.org/10.17816/mechnikov50864
- ID: 50864
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详细
本研究的目的是研究β-内酰胺类抗生素在剖宫产术后子宫内膜炎发生中的药代动力学，以选择最佳的给药方案。
方法。一项前瞻性、随机、单中心研究纳入了52名剖宫产术后子宫内膜炎的妇女，分为四组。第一组（n=17）注射一剂头孢曲松2.0 g，每日1次（n=10），在长期围术期输注模式（n=7）；第二组患者（n=10）注射一剂头孢吡肟2.0 g，每日2次（n=5），在长期输注模式（n=5）；第三组患者（n=14）注射一剂阿莫西林/克拉维酸1.0 g（Amoxiclav® 1000 mg + 200 mg），每日3次（n=7），在长期输注模式（n=7）；第四组患者（n=11）注射一剂氨苄西林/舒巴坦1.0 g（Ampisid® 1000 mg + 500 mg），每日4次（n=6），在长期输注模式（n=5）。采用高效液相色谱法比较四组子宫腔内抗菌药物的浓度。
主要结果。各治疗组的有效杀菌浓度（C>4×MIC）均未在整个剂量间期保持。所研究的抗生素方案的临床疗效和安全性相似。然而，延长输注头孢吡肟和氨青霉素的血性恶露浓度明显升高。
结果。长期静脉输注头孢吡肟、头孢曲松、阿莫西林/克拉维酸、氨苄西林/舒巴坦治疗剖宫产术后子宫内膜炎，与传统的单次给药剂量相比，可改善这些β-内酰胺类药物在宫腔内的药代动力学/药效的特性。
作者简介
Nikolay Korobkov
North-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0001-7279-2535
доцент кафедры акушерства и гинекологии
俄罗斯联邦, Saint PetersburgNatal'ya Bakulina
North-Western State Medical University named after I.I. Mechnikov
Email: nv_bakulina@mail.ru
д.м.н., профессор, зав. кафедрой внутренних болезней, клинической фармакологии и нефрологии
俄罗斯联邦, Saint PetersburgM. Repina
North-Western State Medical University named after I.I. Mechnikov
Email: info@eco-vector.com
д.м.н., профессор
俄罗斯联邦, Saint Petersburg参考
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