Chemiresistive Sensors for Thrombin Assay Based on Nanosize Carbon Nanotube Films on Flexible Supports

Abstract

We present here results obtained during the developmental construction of a selective biological sensor based on carbon nanotubes chemically modified with specific aptamers. The sensory layer, consisting of a film of carbon nanotubes, on a flexible polymer substrate, provides high sensitivity for assay of the target proteins. The responses of the sensory structures to the target protein − thrombin and a reference protein, albumin − were studied. Selective estimation of thrombin after exposure of the sensor to albumin was demonstrated.