Experimental Studies of the Efficacy of Transmyocardial Laser Revascularization Using an Erbium Laser

Abstract

Results obtained using an erbium laser to produce directed angiogenesis in transmyocardial laser revascularization in experiments using an animal model of chronically ischemic myocardium are presented. An assessment of the efficacy of using the erbium laser to produce targeted angiogenesis is presented. The optimum operating regimes for erbium laser pulse irradiation of the myocardium, taking account of thermal tissue lesions, are identified. Morphological changes are investigated and morphometric analysis in tissues in the area of the transmyocardial laser channels are analyzed in a model of chronic ischemic heart disease (IHD) in dogs. Studies were performed for subsequent development and introduction of the new method into clinical practice in patients with IHD with diffuse coronary artery lesions.