Production of Xenogenic Bone Powder for Implants Using Supercritical Fluid Extraction

Abstract

A technology for production of an osteoplastic material (xenogenic bone powder) for implants was developed and brought into use. Implants made of this material can be used in dentistry, periodentistry, maxillofacial surgery, and other branches of medicine. A distinctive feature of the suggested technology is that it uses supercritical fluid extraction for deep defatting and purification of the material. The obtained material was tested for cytotoxicity using and in vitro model. The level of the material's cytotoxicity was reliably shown to be sufficiently low to make it applicable for medical implantation purposes.