


Volume 53, Nº 3 (2019)
- Ano: 2019
- Artigos: 16
- URL: https://journal-vniispk.ru/0006-3398/issue/view/14671
Theory and Design



Article
Detection of Major Lymphocyte Populations by Image Cytometry
Resumo
A detector of cell subpopulations developed at the Institute of Analytical Instrumentation of the Russian Academy of Sciences was used for immunophenotyping lymphocytes from healthy donors and standardized blood samples with normal and low-level cell populations. It has been shown that it is possible (provided that the modern criteria for the accuracy of the analysis are fulfilled) to determine the relative content of the main populations of lymphocytes, including in standard samples with reduced content of T helper cells that mimic the blood of patients with HIV infection.



A Dual-Port Introducer for Mediated Laser-Induced Thermotherapy of Baker’s Cyst
Resumo
The experience in applying a new method of treating patients with Baker’s cyst is described. The method is based on laser-induced thermotherapy using a special dual-port introducer. It has been shown that the use of the developed surgical instruments makes it possible to reduce the time and cost of the procedure and to increase its safety. It also allows the period of rehabilitation to be reduced in comparison with the conventional surgical methods of treatment. Based on the results of the application of the new method and equipment, practical recommendations have been formulated that make it possible to individualize the treatment of patients with Baker’s cyst.



An Experimental Apparatus for Transmyocardial Laser Revascularization Based on an Nd:YAG Laser
Resumo
We present here the results obtained during the development of an experimental apparatus for transmyocardial laser revascularization based on an Nd:YAG laser. Use of laser irradiation with a wavelength of 1.44 μm was shown to be effective in producing targeted angiogenesis in transmyocardial laser revascularization in experimental studies using a model of ischemic myocardium. The optimum regimes for pulsed Nd:YAG laser irradiation of the myocardium with thermal tissue damage were established. Morphological changes in the transmyocardial laser channels in pig myocardium were studied. The objective of the experiments was to confirm the efficacy of using this apparatus for transmyocardial laser revascularization with an Nd:YAG laser for the treatment of patients with diffuse lesions to the coronary arteries.



Design of Individual Components of the Prosthesis for Revision Hip Replacement
Resumo
The number of cases with extensive and complex bone defects undergoing revision endoprosthetization continues to increase. We tested a reendoprosthetization method for hip joints with severe bone tissue deficits using individualized endoprosthesis components in four patients. Clinical data showed that use of a personalized approach to reendoprosthetization of hip joints with severe bone tissue deficit provided complete filling of defects in the acetabulum.



The Effect of Filter Parameters on the Accuracy of ECG Signal Measurement
Resumo
The problem of reducing ECG measurement error by processing ECG signals with physiological and electrical noise is considered. Recommendations are given for selecting the filter passband optimal for minimizing the ECG signal measurement error and, as a consequence, improving the accuracy of measurement of its amplitude and time parameters. The effectiveness of application of a band-pass filter is corroborated by the results of processing of experimental ECG signals.



Investigation of Hemocompatibility of Rotary Blood Pumps: The Case of the Sputnik Ventricular Assist Device
Resumo
The hemocompatibility of Sputnik rotary blood pumps of the first and second generation (Sputnik-1 and Sputnik-2) was studied using numerical simulation. The influence of the flow geometry on scalar shear stresses (SSS), the residence time, and the volume of recirculation zones was determined. Volume fractions of SSS were obtained for the threshold stress levels of 9, 50, and 150 Pa at a fixed pump speed of 8000 rpm (mean flow rate, 4.5 L/min; pressure, 80 mm Hg). At all selected threshold stress levels, the elevated SSS volumes for the first-generation rotor pump were found to exceed those for the second-generation pump. Thus, the latter has a lesser effect on blood cells. The average residence time was found to be 39 and 29 ms for the Sputnik-1 and Sputnik-2 pumps, respectively; the respective recirculation zone volumes were 4.36 and 1.72 mL. The lesser volume of recirculation zones for the second-generation rotor pump reduces the probability of formation of stagnation zones and, therefore, the probability of clotting. The simulation results showed that upgrading the design of the Sputnik rotor pump had a positive effect on its hemocompatibility.



Applying the Allan Variance to the Analysis of Errors of the Expiration Volume Measurement Channel of Mechanical Lung Ventilators
Resumo
The expiration volume measurement channel of a mechanical lung ventilator operating at a low rate of gas mixture flow is considered. The channel components are described in detail. The importance of accurate measurement of gas flow at low rates of mechanical ventilation (especially in neonatal medicine) is substantiated. The Allan variance is suggested as a statistical tool for analyzing the measurement channel errors. The obtained Allan variances, their approximations as sums of exponential functions, and estimates of power spectrum density coefficients of zero-signal noise are presented. The obtained estimates of the main components of the channel error are compared with the parameters of the electronic components used in the measurements. Preliminary recommendations for reduction of errors of the volume measurement channel are given.



Kinetics of Calcium and Phosphate Release from the Surface of Implants Coated Using Different Techniques
Resumo
In this work, the bioavailability of calcium and phosphate from the surface of rods with calcium phosphate coatings applied using different techniques was studied. It was shown that the amounts of released osteotropic elements depend on the coating technique. The differences in the bioavailability of calcium and phosphate should be taken into account in compiling the indications for use of implants coated using different application techniques.



Automated Remote Diagnosis of Dermatological Neoplasms
Resumo
Minimum requirements for techniques of remote and automated diagnostics of skin neoplasms are formulated. For the first time, requests received by the Russian teledermatological service dermatology.ru are analyzed to determine promising directions for the development of techniques of computer analysis of skin neoplasm images.



Perspectives in the Development of Biosensors Based on AlGaN/GaN HEMT
Resumo
The development and investigation of biosensors for the early and rapid diagnosis of a wide spectrum of diseases to provide significant reductions in mortality and loss of working time as a result of timely treatment is a current challenge in many countries. The active progress in biosensor technology is promoted by the fact that it is an interdisciplinary field exploiting advancements in very diverse areas of knowledge: from physiology to nanotechnology and electronics.



Carbon Nanomaterials for the Creation of Biological Sensors for Socially Important Diseases
Resumo
In this article, the main directions in the development of carbon nanomaterial-based biological sensors for rapid analysis of socially significant blood diseases are considered. Carbon nanotubes, graphene, and derivative materials are shown to have potential for use in biosensors and are used to create various types of sensors.



A Method for Evaluating the Signal-to-Noise Ratio in Magnetic Resonance Images
Resumo
Assessment of the signal-to-noise ratio as a control parameter for magnetic resonance imaging (MRI) systems is addressed. Experimental data were used to run a statistical analysis of noise components. Use of a multichannel radio-frequency receiver coil and determination of the coefficient of correction provided the basis of a method for assessing the signal-to-noise ratio of MRI scans.



The Development of Ultrasound Technologies in Medicine
Resumo
We analyze here a multitude of results from research and practical use of low-frequency ultrasound in medicine. The technical bases of ultrasound scan welding, cutting, and hydro-treatment of biological tissues are considered from the perspective of expanding the areas of use of ultrasound and creating novel technical devices.



Clutter Filtering for Diagnostic Ultrasound Color Flow Imaging
Resumo
Clutter filtering plays an important role in constructing a quality color flow map in ultrasound Doppler imaging. Signals from slow-moving tissues and vessel walls are clutter as they often mix with reflections from blood and should be suppressed for the further correct estimation of flow parameters. Their complete suppression in color flow imaging is difficult, because these signals on average are 40-60 dB more powerful than the signals from blood, the length of the Doppler sequence is very short, and there is always a demand for a real-time operation. This article provides a general model of the Doppler signal and discusses filters based on polynomial and adaptive regression, empirical mode decomposition, and prospective combined approaches to blood flow filtering.



Boris Moiseevich Tsukerman − The Founder of the Electroimpulse Therapy Method for the Treatment of Supraventricular Arrhythmia
Resumo
The main biographic details and scientific activity of the Russian electrophysiologist B. M. Tsukerman (1920-2007), who made an enormous contribution to the development and clinical introduction of the electroimpulse method of treating supraventricular arrhythmias, are presented.


