Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment
- Авторы: Stashkevich M.A.1, Khomutov E.V.1, Dumanskii Y.V.1, Matvienko A.G.1, Zinkovich I.I.1
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Учреждения:
- Central Research Laboratory, M. Gorky Donetsk National Medical University
- Выпуск: Том 160, № 5 (2016)
- Страницы: 646-648
- Раздел: Pharmacology and Toxicology
- URL: https://journal-vniispk.ru/0007-4888/article/view/236858
- DOI: https://doi.org/10.1007/s10517-016-3239-z
- ID: 236858
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Аннотация
Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.
Об авторах
M. Stashkevich
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Украина, Donetsk
E. Khomutov
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Украина, Donetsk
Yu. Dumanskii
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Украина, Donetsk
A. Matvienko
Central Research Laboratory, M. Gorky Donetsk National Medical University
Автор, ответственный за переписку.
Email: matviyenko.marina@gmail.com
Украина, Donetsk
I. Zinkovich
Central Research Laboratory, M. Gorky Donetsk National Medical University
Email: matviyenko.marina@gmail.com
Украина, Donetsk
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