Email this article Effect of NO Synthase Blockade on Myocardial Contractility of Hypokinetic Rats during Stimulation of β-Adrenoreceptors
- Authors: Zaripova R.I.1, Ziyatdinova N.I.1, Zefirov T.L.1
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Affiliations:
- Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
- Issue: Vol 161, No 2 (2016)
- Pages: 215-217
- Section: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/237275
- DOI: https://doi.org/10.1007/s10517-016-3378-2
- ID: 237275
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Abstract
Stimulation of β-adrenoreceptors with low (10–8 and 10–7 M) or high (10–6 M) doses of isoproterenol in hypokinetic rats treated with L-NAME (a non-selective blocker of NO synthases) decreased or increased myocardial contractility, respectively. In control rats, all examined doses of isoproterenol used under blockade of NO synthases inhibited myocardial contractility.
About the authors
R. I. Zaripova
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Tatarstan
N. I. Ziyatdinova
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Tatarstan
T. L. Zefirov
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan, Tatarstan
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