Email this article Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro
- Authors: Zyuz’kov G.N.1,2, Zhdanov V.V.1, Udut E.V.1, Miroshnichenko L.A.1, Simanina E.V.1, Polyakova T.Y.1, Chaikovskii A.V.1, Stavrova L.A.1, Udut V.V.1,2, Agafonov V.I.1, Burmina Y.V.1, Danilets M.G.1, Minakova M.Y.1, Dygai A.M.1
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Affiliations:
- E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- National Research Tomsk State University
- Issue: Vol 161, No 2 (2016)
- Pages: 224-227
- Section: General Pathology and Pathophysiology
- URL: https://journal-vniispk.ru/0007-4888/article/view/237284
- DOI: https://doi.org/10.1007/s10517-016-3381-7
- ID: 237284
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Abstract
Involvement of individual JAK kinases in the realization of growth potential of mesenchymal progenitor cells was examined in vitro. Important role of JAK2 and JAK3 in determining the initial level of mitotic activity of progenitor cells was established. The yield of fibroblast CFUF was suppressed under the effect of specific inhibitors of JAK kinases. Blockade of JAK3 increased the rate of progenitor element differentiation. JAK1 had no effect on proliferation and differentiation status of progenitor cells.
About the authors
G. N. Zyuz’kov
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; National Research Tomsk State University
Author for correspondence.
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk; Tomsk
V. V. Zhdanov
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
E. V. Udut
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
L. A. Miroshnichenko
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
E. V. Simanina
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
T. Yu. Polyakova
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
A. V. Chaikovskii
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
L. A. Stavrova
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
V. V. Udut
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; National Research Tomsk State University
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk; Tomsk
V. I. Agafonov
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
Ya. V. Burmina
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
M. G. Danilets
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
M. Yu. Minakova
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
A. M. Dygai
E.D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Russian Federation, Tomsk
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