Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State


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The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×108). Fluoxetine produced an immunostimulatory effect manifested in an increase in the relative and absolute number of IgM antibody-producing cells in the spleen and index of immunoreactivity (CD4/CD8). Administration of fl uoxetine to parental mouse strains without depression (CBA and AKR) had no effect (CBA) or reduced the immune response. The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state.

作者简介

M. Gevorgyan

Research Institute of Physiology and Fundamental Medicine

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Email: gevorgyanmm@ngs.ru
俄罗斯联邦, Novosibirsk

G. Idova

Research Institute of Physiology and Fundamental Medicine

Email: gevorgyanmm@ngs.ru
俄罗斯联邦, Novosibirsk

E. Al’perina

Research Institute of Physiology and Fundamental Medicine

Email: gevorgyanmm@ngs.ru
俄罗斯联邦, Novosibirsk

M. Tikhonova

Research Institute of Physiology and Fundamental Medicine; Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: gevorgyanmm@ngs.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

A. Kulikov

Research Institute of Physiology and Fundamental Medicine

Email: gevorgyanmm@ngs.ru
俄罗斯联邦, Novosibirsk

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