Email this article Short Peptides Regulate Gene Expression
- Authors: Khavinson V.K.1,2,3, Lin’kova N.S.1,4, Tarnovskaya S.I.1,4
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- I. I. Mechnikov North-Western State Medical University
- Peter the Great Polytechnical University
- Issue: Vol 162, No 2 (2016)
- Pages: 288-292
- Section: Methods
- URL: https://journal-vniispk.ru/0007-4888/article/view/238136
- DOI: https://doi.org/10.1007/s10517-016-3596-7
- ID: 238136
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Abstract
Short peptides constitute the system of signal molecules regulating the functions of the organism at the molecular, genetic, subcellular, cellular, and tissue levels. One short peptide can regulate dozens of genes, but the molecular mechanism of this process remains unclear. We suppose that short peptides penetrate through the cytoplasmic and nuclear membrane and bind to DNA. Spatial models of DNA—peptide complexes are constructed for 19 short peptides by the docking method. Some peptides have the same binding sites. Peptides KE and EDP bind agat sequence, peptides KEDW and AED to acct sequence, and peptides AEDL and EDL to ctcc sequence.
About the authors
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; I. I. Mechnikov North-Western State Medical University
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
N. S. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great Polytechnical University
Author for correspondence.
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg
S. I. Tarnovskaya
St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great Polytechnical University
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg
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