Email this article Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2
- Authors: Artyukhov V.G.1, Tyunina O.I.2
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Affiliations:
- Voronezh State University
- N. N. Burdenko Voronezh State Medical University
- Issue: Vol 162, No 3 (2017)
- Pages: 362-365
- Section: Microbiology and Immunology
- URL: https://journal-vniispk.ru/0007-4888/article/view/238209
- DOI: https://doi.org/10.1007/s10517-017-3616-2
- ID: 238209
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Abstract
We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e. CO inhibits the proapoptotic effect of recombinant IL-2).
About the authors
V. G. Artyukhov
Voronezh State University
Author for correspondence.
Email: artyukhov@bio.vsu.ru
Russian Federation, Voronezh
O. I. Tyunina
N. N. Burdenko Voronezh State Medical University
Email: artyukhov@bio.vsu.ru
Russian Federation, Voronezh
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