Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis


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Resumo

Mechanisms of thioredoxin peroxidase secretion by Opisthorchis felineus were studied in vivo and in vitro. Specific antibodies were obtained and used for western blotting and immunohistochemical detection in Syrian hamster model of opisthorchiasis. Secreted thioredoxin peroxidase protein was accumulated in the worm incubation medium under conditions of oxidative stress and in bile duct cells of hamsters with chronic opisthorchiasis.

Sobre autores

V. Petrenko

Federal Research Centre Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of Sciences

Email: pmaria@yandex.ru
Rússia, Novosibirsk

M. Pakharukova

Federal Research Centre Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of Sciences; Research Institute of Molecular Biology and Biophysics

Autor responsável pela correspondência
Email: pmaria@yandex.ru
Rússia, Novosibirsk; Novosibirsk

A. Kovner

Federal Research Centre Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of Sciences

Email: pmaria@yandex.ru
Rússia, Novosibirsk

M. L’vova

Federal Research Centre Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of Sciences

Email: pmaria@yandex.ru
Rússia, Novosibirsk

V. Lyakhovich

Research Institute of Molecular Biology and Biophysics

Email: pmaria@yandex.ru
Rússia, Novosibirsk

V. Mordvinov

Federal Research Centre Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of Sciences; Research Institute of Molecular Biology and Biophysics

Email: pmaria@yandex.ru
Rússia, Novosibirsk; Novosibirsk

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