Email this article Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide
- Authors: Khusnutdinov R.R.1, Boichuk S.V.1
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Affiliations:
- Kazan State Medical University
- Issue: Vol 163, No 2 (2017)
- Pages: 260-262
- Section: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/238801
- DOI: https://doi.org/10.1007/s10517-017-3779-x
- ID: 238801
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Abstract
We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide. The mechanisms of tumor cell sensitivity to temozolomide are complex and are determined by not only the level of O6-methylguanine-DNA-methyltransferase (MGTM) expression, but also activity of oncosuppressor protein p53. A-673 Ewing’s sarcoma cells were found to be the most sensitive to temozolomide, whereas temozolomide-treated SK-LMS-1 leiomyosarcoma cells exhibited signs of cell aging.
About the authors
R. R. Khusnutdinov
Kazan State Medical University
Email: boichuksergei@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
S. V. Boichuk
Kazan State Medical University
Author for correspondence.
Email: boichuksergei@mail.ru
Russian Federation, Kazan, Republic of Tatarstan
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