Email this article Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan
- Authors: Khavinson V.K.1,2, Kormilets D.Y.3, Mar’yanovich A.T.2
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. I. Mechnikov North-Western State Medical University
- S. M. Kirov Military Medical Academy
- Issue: Vol 163, No 5 (2017)
- Pages: 671-676
- Section: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/239183
- DOI: https://doi.org/10.1007/s10517-017-3876-x
- ID: 239183
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Abstract
We have discovered motives of short-chain epigenetically active peptides in some proteins of long-lived African mole rat Heterocephalus glaber. These epigenetic regulators are located in the protein structure between lysine and arginine residues, thus facilitating their release in limited proteolysis. Some of these epigenetic regulators are not found in the proteins of short-lived species — Norway rat Rattus norvegicus and house mouse Mus musculus.
About the authors
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; I. I. Mechnikov North-Western State Medical University
Email: atm52@mail.ru
Russian Federation, St. Petersburg; St. Petersburg
D. Yu. Kormilets
S. M. Kirov Military Medical Academy
Email: atm52@mail.ru
Russian Federation, St. Petersburg
A. T. Mar’yanovich
I. I. Mechnikov North-Western State Medical University
Author for correspondence.
Email: atm52@mail.ru
Russian Federation, St. Petersburg
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