Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase


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Abstract

Validation of the method for studies of glucokinase activators by the spectrophotometric method in an in vitro test system is carried out. The advantage of NAD coenzyme vs. thio-NAD is proven. Manifest activation of glucokinase by MBX-2982 compound (GPR119 agonist) in a wide range of concentrations is demonstrated experimentally.

About the authors

A. A. Spasov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: aspasov@mail.ru
Russian Federation, Volgograd

V. A. Kosolapov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: aspasov@mail.ru
Russian Federation, Volgograd

D. A. Babkov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: aspasov@mail.ru
Russian Federation, Volgograd

O. Yu. Maika

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: aspasov@mail.ru
Russian Federation, Volgograd

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