Email this article Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase
- Authors: Spasov A.A.1, Kosolapov V.A.1, Babkov D.A.1, Maika O.Y.1
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Affiliations:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 5 (2017)
- Pages: 695-698
- Section: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/239198
- DOI: https://doi.org/10.1007/s10517-017-3881-0
- ID: 239198
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Abstract
Validation of the method for studies of glucokinase activators by the spectrophotometric method in an in vitro test system is carried out. The advantage of NAD coenzyme vs. thio-NAD is proven. Manifest activation of glucokinase by MBX-2982 compound (GPR119 agonist) in a wide range of concentrations is demonstrated experimentally.
About the authors
A. A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: aspasov@mail.ru
Russian Federation, Volgograd
V. A. Kosolapov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aspasov@mail.ru
Russian Federation, Volgograd
D. A. Babkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aspasov@mail.ru
Russian Federation, Volgograd
O. Yu. Maika
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: aspasov@mail.ru
Russian Federation, Volgograd
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