Отправить статью по E-mail Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia
- Авторы: Borovskaya T.G.1, Kamalova S.I.1, Krivova N.A.2, Zaeva O.B.2, Poluektova M.E.1, Vychuzhanina A.V.1, Grigor’eva V.A.1, Plotnikov M.B.1, Goldberg V.E.3
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Учреждения:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Research Institute of Biology and Biophysics, National Research Tomsk State University
- Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Выпуск: Том 166, № 1 (2018)
- Страницы: 7-10
- Раздел: General Pathology and Pathophysiology
- URL: https://journal-vniispk.ru/0007-4888/article/view/240792
- DOI: https://doi.org/10.1007/s10517-018-4276-6
- ID: 240792
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Аннотация
The effect of phenolic antioxidants (dihydroquercetin, p-tyrosol, dibornol) on the morphology, functions, and redox processes in the reproductive cells of male rats was studied on the model of experimental pathospermia. All antioxidants reduced the percentage of degenerative forms of spermatozoa. Dibornol was most effective. Dihydroquercetin and p-tyrosol did not increase the total number of spermatozoa and the percentage of their mobile forms. These indicators were improved only by dibornol. After administration of all test drugs, the antioxidant potential of spermatozoa increased and did not significantly differ from the baseline values.
Об авторах
T. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: repropharm@yandex.ru
Россия, Tomsk
S. Kamalova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Россия, Tomsk
N. Krivova
Research Institute of Biology and Biophysics, National Research Tomsk State University
Email: repropharm@yandex.ru
Россия, Tomsk
O. Zaeva
Research Institute of Biology and Biophysics, National Research Tomsk State University
Email: repropharm@yandex.ru
Россия, Tomsk
M. Poluektova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Россия, Tomsk
A. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Россия, Tomsk
V. Grigor’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Россия, Tomsk
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Россия, Tomsk
V. Goldberg
Research Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Россия, Tomsk
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