Growth-Stimulating Effect of Human Platelets Stabilized with Silver Nanoparticles


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Аннотация

We studied proliferative activity of multipotent mesenchymal stromal cells on collagen matrices containing platelets stabilized with silver nanoparticles. Dose-dependent stimulation of the growth of stromal cells without their structural damage was observed in the presence of stabilized platelets in proportion of 20-120 mln per 105 multipotent mesenchymal stromal cells. The same doses of non-stabilized platelets produced less pronounced stimulation effect. In higher doses (≥180 mln) stabilized platelets inhibited cell proliferation and induced their damage. Stabilized platelets enhanced migration of multipotent mesenchymal stromal cells; after formation of the monolayer, they actively colonized deep layer of the collagen matrix. The formed monolayer of multipotent mesenchymal stromal cells survived over 14 days without appreciable cell damage.

Авторлар туралы

M. Makarov

N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Healthcare Department

Хат алмасуға жауапты Автор.
Email: mcsimmc@yandex.ru
Ресей, Moscow

M. Storozheva

N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Healthcare Department

Email: mcsimmc@yandex.ru
Ресей, Moscow

N. Borovkova

N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Healthcare Department

Email: mcsimmc@yandex.ru
Ресей, Moscow

I. Ponomarev

N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Healthcare Department

Email: mcsimmc@yandex.ru
Ресей, Moscow

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