Email this article Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism
- Authors: Pokrovskii V.M.1, Kashina Y.V.1, Kiek O.V.1, Gumerova O.V.2, Gorbunova V.Y.2, Abushkevich V.G.1, Penzhoyan A.G.1, Zabolotskikh N.V.1
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Affiliations:
- Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
- Center for Molecular Genetic Studies, Department of Genetics, Bashkir State Pedagogical University
- Issue: Vol 166, No 4 (2019)
- Pages: 487-488
- Section: Genetics
- URL: https://journal-vniispk.ru/0007-4888/article/view/241129
- DOI: https://doi.org/10.1007/s10517-019-04378-3
- ID: 241129
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Abstract
The regulatory and adaptive status was determined in 202 healthy subjects by the parameters of the cardiorespiratory synchronism probe. We performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase TPH1 (A218C polymorphism) and TPH2 (G703T polymorphism), and serotonin receptors (HTR2C and HTR2A genes). The association of the regulatory and adaptive status of a subject with the polymorphism of serotonergic mediator system genes was revealed.
About the authors
V. M. Pokrovskii
Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: pokrovsky@ksma.ru
Russian Federation, Krasnodar
Yu. V. Kashina
Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
Email: pokrovsky@ksma.ru
Russian Federation, Krasnodar
O. V. Kiek
Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
Email: pokrovsky@ksma.ru
Russian Federation, Krasnodar
O. V. Gumerova
Center for Molecular Genetic Studies, Department of Genetics, Bashkir State Pedagogical University
Email: pokrovsky@ksma.ru
Russian Federation, Ufa, Republic of Bashkortostan
V. Yu. Gorbunova
Center for Molecular Genetic Studies, Department of Genetics, Bashkir State Pedagogical University
Email: pokrovsky@ksma.ru
Russian Federation, Ufa, Republic of Bashkortostan
V. G. Abushkevich
Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
Email: pokrovsky@ksma.ru
Russian Federation, Krasnodar
A. G. Penzhoyan
Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
Email: pokrovsky@ksma.ru
Russian Federation, Krasnodar
N. V. Zabolotskikh
Department of Normal Physiology, Kuban State Medical University, Ministry of Health of the Russian Federation
Email: pokrovsky@ksma.ru
Russian Federation, Krasnodar
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