Мақаланы E-mail арқылы жіберу Oncolytic Activity of the Vaccine Strain of Type 3 Poliovirus on the Model of Rat Glioma C6 Cells
- Авторлар: Sosnovtseva A.O.1,2, Zheltukhin A.O.2, Lipatova A.V.2, Chumakov P.M.2,3, Chekhonin V.P.1,4
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Мекемелер:
- V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation
- V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science
- M. P. Chumakov Federal Research Center for Research and Development of Immunobiological Products, Russian Academy of Sciences
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 167, № 1 (2019)
- Беттер: 111-115
- Бөлім: Methods
- URL: https://journal-vniispk.ru/0007-4888/article/view/241494
- DOI: https://doi.org/10.1007/s10517-019-04472-6
- ID: 241494
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Rat glioma cell line C6 expressing human poliovirus receptor (PVR) and susceptible to polioviruses (C6-PVR-BFP) was used to produce a clone with knockout of IFNα/β (Ifnar1) receptor subunit 1 gene (Ifnar1). The sensitivity of C6-PVR-BFP cells to the vaccine strain of poliovirus type 3 (PV3) depended on the signaling pathways of the cell response to type 1 IFN. Using the model of subcutaneous tumor xenografts, we demonstrated oncolytic activity of PV3 against C6-PVR-BFP cells that depended on the expression of PVR and increased considerably upon disturbances in IFN response pathways.
Авторлар туралы
A. Sosnovtseva
V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science
Хат алмасуға жауапты Автор.
Email: aososnovtceva@gmail.com
Ресей, Moscow; Moscow
A. Zheltukhin
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science
Email: aososnovtceva@gmail.com
Ресей, Moscow
A. Lipatova
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science
Email: aososnovtceva@gmail.com
Ресей, Moscow
P. Chumakov
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Science; M. P. Chumakov Federal Research Center for Research and Development of Immunobiological Products, Russian Academy of Sciences
Email: aososnovtceva@gmail.com
Ресей, Moscow; Moscow
V. Chekhonin
V. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: aososnovtceva@gmail.com
Ресей, Moscow; Moscow
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