Email this article Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice
- Authors: Gromov A.V.1, Bartov M.S.1, Orlova P.A.1, Manskikh V.N.1,2, Krivozubov M.S.1, Grunina T.M.1, Manukhina M.S.1, Strukova N.V.1, Nikitin K.E.1, Lunin V.G.1,3, Karyagina A.S.1,2,3, Gintsburg A.L.1
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Affiliations:
- N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- All-Russian Research Institute of Agricultural Biotechnology
- Issue: Vol 167, No 3 (2019)
- Pages: 408-412
- Section: Article
- URL: https://journal-vniispk.ru/0007-4888/article/view/241763
- DOI: https://doi.org/10.1007/s10517-019-04538-5
- ID: 241763
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Abstract
Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.
About the authors
A. V. Gromov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
M. S. Bartov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
P. A. Orlova
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
V. N. Manskikh
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow; Moscow
M. S. Krivozubov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
T. M. Grunina
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
M. S. Manukhina
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
N. V. Strukova
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
K. E. Nikitin
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
V. G. Lunin
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; All-Russian Research Institute of Agricultural Biotechnology
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow; Moscow
A. S. Karyagina
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; All-Russian Research Institute of Agricultural Biotechnology
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow; Moscow; Moscow
A. L. Gintsburg
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Russian Federation, Moscow
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