Cytokine-producing function of human blood cells in chronic atrophic gastritis and gastric adenomas and adenocarcinomas

A. V. Sosnina; A. I. Autenshlyus; E. S. Mikhailova; D. V. Morozov; A. V. Vankhalsky; L. A. Shpagina; N. A. Varaksin; V. V. Lyakhovich

doi:10.1134/S001249661602006X

Cytokine-producing function of human blood cells in chronic atrophic gastritis and gastric adenomas and adenocarcinomas

Authors: Sosnina A.V.¹, Autenshlyus A.I.¹, Mikhailova E.S.¹, Morozov D.V.¹, Vankhalsky A.V.², Shpagina L.A.², Varaksin N.A.³, Lyakhovich V.V.¹
Affiliations:
1. Research Institute of Molecular Biology and Biophysics, Siberian Branch
2. Novosibirsk State Medical University
3. Vektor-Best
Issue: Vol 467, No 1 (2016)
Pages: 93-95
Section: Cell Biology
URL: https://journal-vniispk.ru/0012-4966/article/view/153697
DOI: https://doi.org/10.1134/S001249661602006X
ID: 153697

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Abstract

The cytokine-producing potential of blood cells has been studied in the atrophic gastritis–adenoma–adenocarcinoma progression of pathological states of the stomach. It has been revealed that, at the initial stage of carcinogenesis, namely adenoma, immunocompetent cells have the highest cytokine-producing proto-oncogenic potential as compared to both atrophic gastritis, which presents a precancerous condition, and completely formed malignant tumor (gastric adenocarcinoma).