Email this article Memantine attenuates cognitive impairments after status epilepticus induced in a lithium–pilocarpine model
- Authors: Kalemenev S.V.1, Zubareva O.E.1,2, Sizov V.V.2, Lavrent’eva V.V.1, Lukomskaya N.Y.1, Kim K.K.1, Zaitsev A.V.1, Magazanik L.G.1,3
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Affiliations:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Institute of Experimental Medicine
- St. Petersburg State University
- Issue: Vol 470, No 1 (2016)
- Pages: 224-227
- Section: Physiology
- URL: https://journal-vniispk.ru/0012-4966/article/view/153845
- DOI: https://doi.org/10.1134/S0012496616050148
- ID: 153845
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Abstract
The capability of memantine, a noncompetitive antagonist of the NMDA receptors, to prevent impairments of cognitive functions in rats was investigated in the lithium–pilocarpine model of epilepsy. After status epilepticus, rats exhibited impaired exploratory behavior and spatial memory, and a decline of extinction of orienting behavior. Memantine administration prevented these disturbances. Thus, the blockade of the NMDA receptors immediately after status epilepticus allowed prevention of the development of the possible cognitive impairments.
About the authors
S. V. Kalemenev
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg
O. E. Zubareva
Sechenov Institute of Evolutionary Physiology and Biochemistry; Institute of Experimental Medicine
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
V. V. Sizov
Institute of Experimental Medicine
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg
V. V. Lavrent’eva
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg
N. Ya. Lukomskaya
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg
K. Kh. Kim
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg
A. V. Zaitsev
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg
L. G. Magazanik
Sechenov Institute of Evolutionary Physiology and Biochemistry; St. Petersburg State University
Author for correspondence.
Email: levmagazanik100@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
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