Email this article Effect of polypeptides from sea anemone Heteractis crispa on the rodent blood pressure, heart rate, and hemostasis
- Authors: Skobtsova L.A.1,2, Dyachenko I.A.1,2, Andreev Y.A.3, Logashina Y.A.3, Murashev A.N.1,2, Grishin E.V.3
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Affiliations:
- Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Pushchino State Institute of Natural Sciences
- Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry
- Issue: Vol 470, No 1 (2016)
- Pages: 228-230
- Section: General Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/153852
- DOI: https://doi.org/10.1134/S0012496616050069
- ID: 153852
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Abstract
АРНС1–3 peptides, modulators of TRPV1 receptors, have been administered to SD rats to study their influence on the animal hemostatic system, heart rate, and blood pressure. None of АЗРС1–3 polypeptides have any effect on the hemostatic system. Both АРНС1 and АРНС2 polypeptides increased significantly the heart rate, but they did not affect blood pressure, which was probably caused by an ability of these polypeptides to modify animal thermoregulation.
About the authors
L. A. Skobtsova
Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, Pushchino, Moscow oblast; Pushchino, Moscow oblast
I. A. Dyachenko
Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pushchino State Institute of Natural Sciences
Author for correspondence.
Email: dyachenko@bibch.ru
Russian Federation, Pushchino, Moscow oblast; Pushchino, Moscow oblast
Ya. A. Andreev
Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry
Email: dyachenko@bibch.ru
Russian Federation, Moscow
Yu. A. Logashina
Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry
Email: dyachenko@bibch.ru
Russian Federation, Moscow
A. N. Murashev
Pushchino Branch, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, Pushchino, Moscow oblast; Pushchino, Moscow oblast
E. V. Grishin
Shemyakm–Ovchinnikov Institute of Bioorganic Chemistry
Email: dyachenko@bibch.ru
Russian Federation, Moscow
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