Hypothermia-Induced Postrepolarization Refractoriness Is the Reason of the Atrial Myocardium Tolerance to the Bioelectrical Activity Disorders in the Hibernating and Active Ground Squirrel Citellus undulatus

Abstract

The electrophysiological mechanism of the atrial myocardium resistance to the cold-induced arrhythmias was studied in the hibernating ground squirrel Citellus undulatus. The atrial action potentials (APs) and refractoriness were recorded with microelectrodes in isolated multicellular preparations of the atrial myocardium taken from the hibernating and summer active ground squirrels (HS and SAS, respectively) at 37, 27, and 17°С to estimate the AP and refractoriness durations. In both HS and SAS, hypothermia increased the duration of the AP and refractoriness period (APD and RD, respectively), and in both animal groups RD was longer than APD under hypothermia but not at 37°С. This last observation can be a result of the postrepolarization refractoriness (PRR), which seems to contribute substantially to the atrial myocardium tolerance of the hibernating animals to the hypothermia-induced arrhythmias because it prevents afterdepolarizations.