Enviar artigo por via de e-mail Development of a Biocompatible and Biodegradable Polymer Capable of Long-Term Release of Biologically Active Substances for Medicine and Agriculture
- Autores: Baikin A.S.1, Kaplan M.A.1, Nasakina E.O.1, Shatova L.A.2, Tsareva A.M.1, Kolmakova A.A.1, Danilova E.A.1, Tishurova Y.A.3,4, Bunkin N.F.3,4, Gudkov S.V.4,5,6, Belosludtsev K.N.7, Glinushkin A.P.6, Kolmakov A.G.1, Sevostyanov M.A.1,6,8
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Afiliações:
- Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
- Voronezh State Technical University
- Bauman Moscow State Technical University (National Research University)
- Prokhorov General Physics Institute, Russian Academy of Sciences
- Lobachevsky State University of Nizhny Novgorod— National Research University
- All-Russian Research Institute of Phytopathology
- Mari State University
- Ugresha Branch, State University “Dubna”
- Edição: Volume 489, Nº 1 (2019)
- Páginas: 261-263
- Seção: Chemistry
- URL: https://journal-vniispk.ru/0012-5008/article/view/154531
- DOI: https://doi.org/10.1134/S0012500819110041
- ID: 154531
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Resumo
A process was developed for producing biocompatible and biodegradable polymer films based on high-molecular-weight polylactide with properties necessary for medical and agricultural applications. A method was devised for the inclusion of active substances (gentamicin sulfate, lincomycin hydrochloride, or cefotaxime) into high-molecular-weight polylactide films. The rate of release of active substances from polylactide can vary with time according to a decaying exponential law or nearly linearly. The release of active substances is significantly affected by pH of the solution surrounding the film. It was found that the dynamics of release of active substances from biocompatible biodegradable polymer films based on high-molecular-weight polylactide depends on the properties of the immobilized substance, the film preparation method, and the conditions of extraction. The biocompatible biodegradable polymer films based on high-molecular-weight polylactide are quite suitable for the manufacture of coatings for stents and prostheses with prolonged and controlled drug release into the surrounding tissues and for agricultural applications to improve crop preservation.
Sobre autores
A. Baikin
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Autor responsável pela correspondência
Email: baikinas@mail.ru
Rússia, Moscow, 119334
M. Kaplan
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 119334
E. Nasakina
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 119334
L. Shatova
Voronezh State Technical University
Email: baikinas@mail.ru
Rússia, Voronezh, 394026
A. Tsareva
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 119334
A. Kolmakova
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 119334
E. Danilova
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 119334
Ya. Tishurova
Bauman Moscow State Technical University (National Research University); Prokhorov General Physics Institute, Russian Academyof Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 105043; Moscow
N. Bunkin
Bauman Moscow State Technical University (National Research University); Prokhorov General Physics Institute, Russian Academyof Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 105043; Moscow
S. Gudkov
Prokhorov General Physics Institute, Russian Academyof Sciences; Lobachevsky State University of Nizhny Novgorod— National Research University; All-Russian Research Institute of Phytopathology
Email: baikinas@mail.ru
Rússia, Moscow; Nizhny Novgorod; Bolshie Vyazemy, Moscow oblast
K. Belosludtsev
Mari State University
Email: baikinas@mail.ru
Rússia, Yoshkar-Ola
A. Glinushkin
All-Russian Research Institute of Phytopathology
Email: baikinas@mail.ru
Rússia, Bolshie Vyazemy, Moscow oblast
A. Kolmakov
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Email: baikinas@mail.ru
Rússia, Moscow, 119334
M. Sevostyanov
Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences; All-Russian Research Institute of Phytopathology; Ugresha Branch, State University “Dubna”
Email: baikinas@mail.ru
Rússia, Moscow, 119334; Bolshie Vyazemy, Moscow oblast; Dzerzhynsk, Moscow oblast
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