БАКТЕРИАЛЬНЫЕ БИОПЛЕНКИ КАК РЕЗЕРВУАР АМИЛОИДОВ, ОБРАЗУЮЩИХСЯ ЗА СЧЕТ СПЕЦИФИЧЕСКИХ И НЕСПЕЦИФИЧЕСКИХ МЕХАНИЗМОВ

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Аннотация

Амилоидами называют белковые агрегаты с фибриллярной морфологией и особой пространственной структурой, называемой «кросс-β». Амилоиды известны уже более 150 лет, и многие из них ассоциированы с развитием преимущественно неизлечимых заболеваний человека, называемых амилоидозами, некоторые из которых, например болезнь Альцгеймера, имеют высокую социальную значимость. На рубеже XXI в. было установлено, что амилоиды не только представляют собой результат нарушения укладки белка, но участвуют в выполнении биологических функций у представителей всех трех доменов живого мира: архей, бактерий и эукариот, включая человека. Наибольшее разнообразие функциональных амилоидов описано у бактерий, у которых эти белковые агрегаты вовлечены преимущественно в процессы формирования биопленок, играющих важную роль в развитии бактериальных инфекций и антибиотикорезистентности. Амилоидные фибриллы являются важным структурным компонентом матрикса биопленок у различных групп бактерий. Несмотря на то что некоторые бактериальные амилоиды формируются при помощи специфических систем секреции и сборки, механизмы формирования целого ряда из них, включая амилоидные формы белков наружной мембраны и компонентов аппарата трансляции, неясны. Накопленные к настоящему времени данные позволяют предположить, что в формировании таких амилоидов могут быть задействованы более общие, «неспецифические» механизмы, включающие регулируемую клеточную гибель во время развития биопленок.

Об авторах

А. А. Нижников

Санкт-Петербургский государственный университет; Всероссийский научно-исследовательский институт сельскохозяйственной микробиологии

Email: a.nizhnikov@spbu.ru
Санкт-Петербург, Россия; Санкт-Петербург, Пушкин, Россия

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