Effect of histidine-containing dipeptides on the free-radical fragmentation of biologically active phospho derivatives of glycerol
- Authors: Shendikova E.N.1, Mel’sitova I.V.2, Yurkova I.L.1,2
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Affiliations:
- Research Institute of Physicochemical Problems
- Belarussian State University
- Issue: Vol 50, No 4 (2016)
- Pages: 249-253
- Section: Radiation Chemistry
- URL: https://journal-vniispk.ru/0018-1439/article/view/156988
- DOI: https://doi.org/10.1134/S0018143916040172
- ID: 156988
Cite item
Abstract
The effects of carnosine, anserine, and glycyl-histidine on the free-radical fragmentation of glycero-1-phosphate and dimiristoyl phosphatidylglycerol induced by γ-radiation or Fe2+(Cu2+)-containing systems have been studied. The histidine-containing dipeptides (HCDs) exert a radioprotector effect on the fragmentation; this effect depends on the concentration of O2 and reaches a maximum in deaerated systems (by a factor of ~1.7). The HCDs can be antior prooxidants under the conditions of the Fe2+(Cu2+)-mediated generation of HO· radicals. Carnosine exhibits protector properties in a dose-dependent manner regardless of the inductor. Carnosine more effectively inhibits Cu2+-induced fragmentation (by a factor of 2–2.5) than the Fe2+-mediated process (by a factor of 1.4).
About the authors
E. N. Shendikova
Research Institute of Physicochemical Problems
Email: yurkovail@tut.by
Belarus, ul. Leningradskaya 14, Minsk, 220030
I. V. Mel’sitova
Belarussian State University
Email: yurkovail@tut.by
Belarus, ul. Leningradskaya 14, Minsk, 220030
I. L. Yurkova
Research Institute of Physicochemical Problems; Belarussian State University
Author for correspondence.
Email: yurkovail@tut.by
Belarus, ul. Leningradskaya 14, Minsk, 220030; ul. Leningradskaya 14, Minsk, 220030
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