Substrate Specificity of Cholinesterases in Various Representatives of the Animal Kingdom
- Autores: Basova N.E.1, Kormilitsyn B.N.1, Perchenok A.Y.1, Rozengart E.V.1, Saakov V.S.1, Suvorov A.A.1
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Afiliações:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- Edição: Volume 54, Nº 3 (2018)
- Páginas: 157-174
- Seção: Reviews
- URL: https://journal-vniispk.ru/0022-0930/article/view/159471
- DOI: https://doi.org/10.1134/S0022093018030018
- ID: 159471
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Resumo
This review summarizes the literature data as well as experimental results obtained at our Institute over a period of 50 years on the substrate specificity of cholinesterases–acetylcholine acetylhydrolases (EC 3.1.1.7) and acylcholine acylhydrolases (EC 3.1.1.8). The parameters of enzymatic hydrolysis of oxo- and thiocholine and β-methylcholine esters in different organs and tissues were analyzed in 66 animal species including 22 chordate, 20 insect, 1 mite, 17 mollusk, 4 nematode, and 2 flatworm species. Our substrate specificity studies and extensive data on the inhibitory specificity obtained using irreversible organophosphorous inhibitors and reversible effectors unequivocally indicate that the cholinesterase family is characterized by a clear-cut species and tissue specificity.
Sobre autores
N. Basova
Sechenov Institute of Evolutionary Physiology and Biochemistry
Autor responsável pela correspondência
Email: roz@iephb.ru
Rússia, St. Petersburg
B. Kormilitsyn
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: roz@iephb.ru
Rússia, St. Petersburg
A. Perchenok
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: roz@iephb.ru
Rússia, St. Petersburg
E. Rozengart
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: roz@iephb.ru
Rússia, St. Petersburg
V. Saakov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: roz@iephb.ru
Rússia, St. Petersburg
A. Suvorov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: roz@iephb.ru
Rússia, St. Petersburg
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