Structure and urease inhibitory activity of copper(II) complex with (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid

Abstract

A new caffeic acid derivative ((E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid, HL¹)) is synthesized from caffeic acid, followed by the preparation of a Cu(II) complex, [Cu₂(L¹)₄DMSO₂]·2DMSO. The structure is determined by single crystal X-ray diffraction, and the urease inhibitory activity of the complex is studied. The results show that IC₅₀ of the complex is 0.56 μmol/L, which is superior to positive control acetohydroxamic acid (AHA, IC₅₀ was 10.95 μmol/l), i.e., the complex has strong inhibitory activity towards urease.