Email this article Structure, DNA bonding, and biological activity of a novel Pb(II) complex of 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane
- Authors: Gao E.1, Meng B.1, Su J.1, Peng T.1, Qi Z.1, Jia B.1, Feng Y.1, Zhu M.1
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Affiliations:
- Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
- Issue: Vol 58, No 8 (2017)
- Pages: 1560-1566
- Section: Article
- URL: https://journal-vniispk.ru/0022-4766/article/view/161706
- DOI: https://doi.org/10.1134/S0022476617080121
- ID: 161706
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Abstract
A novel complex [Pb(bptm)(NO3)(H2O)2] (bptm = 1,1-bis(5-(pyrazin-2-yl)-1,2,4-triazol-3-yl) methane) is synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction. Its reactivity with calf thymus DNA and HeLa cell DNA is measured using UV absorption and fluorescence spectroscopies. Gel electrophoresis assay demonstrates the ability of the complex to cleave pBR322 plasmid DNA. Eventually, the complex can suitably dock with a special DNA.
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About the authors
E.-J. Gao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
B. Meng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
J.-Q. Su
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
T.-T. Peng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
Z.-Z. Qi
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
B. Jia
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
Y.-H. Feng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang
M.-C. Zhu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Author for correspondence.
Email: mczhu@syuct.edu.cn
China, Shenyang
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