Two Novel Tungstate Metal-Organic Complexes: Crystal Structures and Anticancer Activity in Osteogenic Sarcoma

Abstract

Two novel metal-organic compounds based on tungstate–[Ni(HL₁)₂(Mo₈O₂₆)]·5H₂O (1, L₁ = 4-[5-(1H-pyrazol-4-yl)-4H-[1,2,4]triazol-3-yl]-pyridine) and [{Ni₄(L₂)₄(H₂O)₆}(H₃PMo₁₂O₄₀)]× 7H₂O (2, L₂ = 2-(3-carboxypyridin-2-yl) nicotinic acid)–are hydrothermally synthesized and characterized by single crystal X-ray diffraction as well as elemental analysis. In addition, the in vitro anticancer activity of compounds 1 and 2 on three human osteogenic sarcoma cells (MG63, U2OS, and 143B) is further determined via the MTT assay.