Structural Reorganization of Cell Membrane Models Caused by the Anticancer Antibiotic Doxorubicin

N. N. Novikova; Новикова Н. Н.; M. V. Kovalchuk; Ковальчук М. В.; A. V. Rogachev; Рогачев А. В.; Yu. N. Malakhova; Малахова Ю. Н.; Yu. O. Kotova; Котова Ю. О.; S. E. Gelperina; Гельперина С. Э.; S. N. Yakunin; Якунин С. Н.

doi:10.31857/S0023476123600842

Structural Reorganization of Cell Membrane Models Caused by the Anticancer Antibiotic Doxorubicin

Authors: Novikova N.N.¹, Kovalchuk M.V.¹, Rogachev A.V.¹, Malakhova Y.N.¹^,2, Kotova Y.O.³, Gelperina S.E.³, Yakunin S.N.¹
Affiliations:
1. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia
2. MIREA—Rusian Technological University, Moscow, Russia
3. Mendeleev University of Chemical Technology, 125047, Moscow, Russia
Issue: Vol 68, No 6 (2023)
Pages: 990-1001
Section: ПОВЕРХНОСТЬ, ТОНКИЕ ПЛЕНКИ
URL: https://journal-vniispk.ru/0023-4761/article/view/231852
DOI: https://doi.org/10.31857/S0023476123600842
EDN: https://elibrary.ru/AAUWIR
ID: 231852

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Abstract
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Abstract

The molecular mechanisms of the interaction of anticancer antibiotic doxorubicin with lipid cell membrane models have been investigated using grazing incidence X-ray diffraction (XRD) and X-ray reflectivity (XRR). The model systems were monolayers of four types of phospholipids, related to the main components of animal cell membranes. New information on the processes of damage of phospholipid monolayer lattice caused by doxorubicin is obtained. It is established that the action of doxorubicin on anionic phospholipid monolayers is determined by the electrostatic interaction: positively charged doxorubicin molecules are incorporated between negatively charged phospholipid functional groups. In the case of neutral phospholipids the key role belongs to the hydrophobic interaction: doxorubicin molecules are coordinated with phospholipid hydrocarbon tails in disordered regions.

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