Email this article An Overlap between Splicing Sites in RNA and Homo-Repeats in Human Proteins
- Authors: Galzitskaya O.V.1, Novikov G.S.2
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Affiliations:
- Institute of Protein Research, Russian Academy of Sciences
- Nanotechnology Research and Education Center, St. Petersburg National Academic Research University
- Issue: Vol 53, No 3 (2019)
- Pages: 470-474
- Section: Proteomics
- URL: https://journal-vniispk.ru/0026-8933/article/view/163990
- DOI: https://doi.org/10.1134/S0026893319030063
- ID: 163990
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Abstract
Proteins with homo-repeats of more than 4 amino acid residues in length were examined to understand whether some splicing sites in pre-mRNA may be attributed to homo-repeats in human proteins. The human proteome was found to contain a total of 404 proteins with homo-repeats that account for at least one splicing site in pre-mRNA. Pre-mRNA splicing sites were more often found in the C-terminal part (67%) than in the middle or N-terminal part of a homo-repeat. Ten homo-repeats were identified to have two splicing sites per repeat. The repeats were lysine homo-repeats in all but one case.
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About the authors
O. V. Galzitskaya
Institute of Protein Research, Russian Academy of Sciences
Author for correspondence.
Email: ogalzit@vega.protres.ru
Russian Federation, Pushchino, Moscow oblast, 142290
G. S. Novikov
Nanotechnology Research and Education Center, St. Petersburg National Academic Research University
Email: ogalzit@vega.protres.ru
Russian Federation, St. Petersburg, 194021
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