Cryochemical synthesis and antibacterial activity of a hybrid composition based on Ag nanoparticles and dioxidine

Abstract

Hybrid nanocomposites based on an dioxidine antimicrobial substance modified with silver were produced by means of cryochemical synthesis. TEM, UV-absorption spectroscopy, X-ray diffraction, and surface analysis based on low-temperature argon adsorption showed the formation of hybrid nanosystems consisting of drug substance particles with a size of 50–300 nm including internal small Ag nanoparticles with a size of 2–40 nm. The obtained hybrid nanosystems showed higher antibacterial activity against E. coli 52, S. aureus 144, and M. cyaneum 98 than did the original dioxidine.