New Opportunities for Colorectal Cancer Diagnostics Using an Optical Cell Detection System Based on Dielectrophoresis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The possibilities of using electrical and viscoelastic parameters of erythrocytes in patients with colorectal cancer (CRC) of different stages were demonstrated using optical cell detection system based on the dielectrophoresis method. The deformation amplitude, portion of deformed cells, generalized viscosity, rigidity, equilibrium frequency position, and electrical conductivity were the most significant parameters for determining patients with CRC, as well as early and late stages, included in the created model of a riskometer for the disease diagnosis. The created diagnostic “panels” with a high diagnostic accuracy, sensitivity, and specificity allowed to one determine patients with CRC (specificity 0.91, sensitivity 0.96), as well as early and late stages of the disease (specificity 0.64, sensitivity 0.86).

About the authors

M. V. Kruchinina

Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics,
Siberian Branch, Russian Academy of Sciences; Novosibirsk State Medical University

Author for correspondence.
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630089; Novosibirsk, 630091

Ya. I. Prudnikova

Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics,
Siberian Branch, Russian Academy of Sciences

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630089

A. A. Gromov

Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics,
Siberian Branch, Russian Academy of Sciences

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630089

V. M. Generalov

State Research Center of Virology and Biotechnology Vector, 
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, Koltsovo, 630559

K. V. Generalov

State Research Center of Virology and Biotechnology Vector, 
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, Koltsovo, 630559

V. N. Kruchinin

Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630090

E. V. Kruchinina

Novosibirsk State Medical University

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630091

G. V. Shuvalov

Siberian Scientific Research Institute of Metrology

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630004

I. N. Yakovina

Novosibirsk State Technical University

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630073

N. A. Bannova

Novosibirsk State Technical University

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630073

O. V. Minin

Tomsk State University

Email: kruchmargo@yandex.ru
Russian Federation, Tomsk, 634050

I. V. Minin

Siberian Scientific Research Institute of Metrology

Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630004

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Pleiades Publishing, Ltd.