New Opportunities for Colorectal Cancer Diagnostics Using an Optical Cell Detection System Based on Dielectrophoresis
- Authors: Kruchinina M.V.1,2, Prudnikova Y.I.1, Gromov A.A.1, Generalov V.M.3, Generalov K.V.3, Kruchinin V.N.4, Kruchinina E.V.2, Shuvalov G.V.5, Yakovina I.N.6, Bannova N.A.6, Minin O.V.7, Minin I.V.5
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Affiliations:
- Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State Medical University
- State Research Center of Virology and Biotechnology Vector, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences
- Siberian Scientific Research Institute of Metrology
- Novosibirsk State Technical University
- Tomsk State University
- Issue: Vol 126, No 5 (2019)
- Pages: 568-573
- Section: Biophotonics
- URL: https://journal-vniispk.ru/0030-400X/article/view/165995
- DOI: https://doi.org/10.1134/S0030400X19050163
- ID: 165995
Cite item
Abstract
The possibilities of using electrical and viscoelastic parameters of erythrocytes in patients with colorectal cancer (CRC) of different stages were demonstrated using optical cell detection system based on the dielectrophoresis method. The deformation amplitude, portion of deformed cells, generalized viscosity, rigidity, equilibrium frequency position, and electrical conductivity were the most significant parameters for determining patients with CRC, as well as early and late stages, included in the created model of a riskometer for the disease diagnosis. The created diagnostic “panels” with a high diagnostic accuracy, sensitivity, and specificity allowed to one determine patients with CRC (specificity 0.91, sensitivity 0.96), as well as early and late stages of the disease (specificity 0.64, sensitivity 0.86).
About the authors
M. V. Kruchinina
Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics,Siberian Branch, Russian Academy of Sciences; Novosibirsk State Medical University
Author for correspondence.
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630089; Novosibirsk, 630091
Ya. I. Prudnikova
Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics,Siberian Branch, Russian Academy of Sciences
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630089
A. A. Gromov
Research Institute of Internal and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics,Siberian Branch, Russian Academy of Sciences
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630089
V. M. Generalov
State Research Center of Virology and Biotechnology Vector,Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, Koltsovo, 630559
K. V. Generalov
State Research Center of Virology and Biotechnology Vector,Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, Koltsovo, 630559
V. N. Kruchinin
Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630090
E. V. Kruchinina
Novosibirsk State Medical University
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630091
G. V. Shuvalov
Siberian Scientific Research Institute of Metrology
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630004
I. N. Yakovina
Novosibirsk State Technical University
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630073
N. A. Bannova
Novosibirsk State Technical University
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630073
O. V. Minin
Tomsk State University
Email: kruchmargo@yandex.ru
Russian Federation, Tomsk, 634050
I. V. Minin
Siberian Scientific Research Institute of Metrology
Email: kruchmargo@yandex.ru
Russian Federation, Novosibirsk, 630004
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