Solid Lipid Curcumin-loaded Particles for in vivo Fluorescent Imaging in Humans: A Proof of Concept


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The possibility to use oral intake of fluorescent dyes approved on humans for intravital fluorescence in vivo imaging is attractive due to its simplicity and non-invasive character. Here we investigate the potential of solid lipid curcumin particles (SLCP) for imaging of capillary permeability using fluorescence video capillaroscopy. Curcumin fluorescence corresponding to 0.7 μg/mL concentration was observed from blood plasma after oral consumption of 2 g of SLCP. However, this signal was ~15% higher than that of blood plasma intrinsic fluorescence, which was itself at least 10-fold lower than the background signal from pericapillary tissue. By comparing the optical properties and concentration to the case of intravenous injection of sodium fluorescein, we analyzed which parameters of the experiment should be optimized for using oral consumption of fluorescing compounds in intravital in vivo capillaroscopy measurements.

作者简介

T. Tikhonova

International Laser Center, Lomonosov Moscow State University

Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 119991

Y. Gurfinkel

Lomonosov Moscow State University Clinic

Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 119991

V. Fadeev

Lomonosov Moscow State University, Faculty of Physics

Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 119991

J. Lademann

Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin,
and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology,
Center of Experimental and Applied Cutaneous Physiology (CCP)

Email: shirshin@lid.phys.msu.ru
德国, Berlin, 10117

M. Darvin

Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin,
and Berlin Institute of Health, Department of Dermatology, Venerology and Allergology,
Center of Experimental and Applied Cutaneous Physiology (CCP)

Email: shirshin@lid.phys.msu.ru
德国, Berlin, 10117

E. Shirshin

Lomonosov Moscow State University, Faculty of Physics

编辑信件的主要联系方式.
Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 119991

M. Gogoleva

Lomonosov Moscow State University, Faculty of Physics

Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 119991

B. Yakimov

Lomonosov Moscow State University, Faculty of Physics

Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 119991

S. Rodionov

N.N. Priorov Central Institute for Traumatology and Orthopedics

Email: shirshin@lid.phys.msu.ru
俄罗斯联邦, Moscow, 127299

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