Email this article A Complex Study of the Peculiarities of Blood Serum Absorption of Rats with Experimental Liver Cancer
- Authors: Nazarov M.M.1, Cherkasova O.P.2,3,4, Lazareva E.N.3,5, Bucharskaya A.B.6, Navolokin N.A.6, Tuchin V.V.3,5,7, Shkurinov A.P.8,9
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Affiliations:
- National Research Centre Kurchatov Institute
- Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences
- Tomsk State University
- Novosibirsk State Technical University
- Saratov State University
- Saratov State Medical University
- Institute of Precision Mechanics and Control, Russian Academy of Sciences
- Moscow State University
- Institute for Problems of Laser and Information Technologies of the Russian Academy of Sciences, Branch of Federal Scientific Research Center Crystallography and Photonics
- Issue: Vol 126, No 6 (2019)
- Pages: 721-729
- Section: Biophotonics
- URL: https://journal-vniispk.ru/0030-400X/article/view/166017
- DOI: https://doi.org/10.1134/S0030400X19060183
- ID: 166017
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Abstract
Terahertz time-domain spectroscopy (THz-TDS) in the 0.05–1.0 THz frequency range was used to study the blood serum of rats in the dynamics of experimental liver cancer. It was shown that the THz transmission spectra of samples from healthy animals and 14 and 28 days after tumor cells implantation are similar in shape, but differ in amplitude. There is a change in the biochemical composition of the blood, including a decrease in the protein content, by the 28th day of the experiment. The observed changes in the THz response are explained by a decrease in the number of protein molecules and bound water and correlate with changes in the refractive index in the visible and near-IR ranges from 480 to 1550 nm, measured using a multiwave refractometer.
About the authors
M. M. Nazarov
National Research Centre Kurchatov Institute
Email: o.p.cherkasova@gmail.com
Russian Federation, Moscow, 123182
O. P. Cherkasova
Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences; Tomsk State University; Novosibirsk State Technical University
Author for correspondence.
Email: o.p.cherkasova@gmail.com
Russian Federation, Novosibirsk, 630090; Tomsk, 634050; Novosibirsk, 630073
E. N. Lazareva
Tomsk State University; Saratov State University
Email: o.p.cherkasova@gmail.com
Russian Federation, Tomsk, 634050; Saratov, 410012
A. B. Bucharskaya
Saratov State Medical University
Email: o.p.cherkasova@gmail.com
Russian Federation, Saratov, 410012
N. A. Navolokin
Saratov State Medical University
Email: o.p.cherkasova@gmail.com
Russian Federation, Saratov, 410012
V. V. Tuchin
Tomsk State University; Saratov State University; Institute of Precision Mechanics and Control, Russian Academy of Sciences
Email: o.p.cherkasova@gmail.com
Russian Federation, Tomsk, 634050; Saratov, 410012; Saratov, 410028
A. P. Shkurinov
Moscow State University; Institute for Problems of Laser and Information Technologies of the Russian Academy of Sciences,Branch of Federal Scientific Research Center Crystallography and Photonics
Email: o.p.cherkasova@gmail.com
Russian Federation, Moscow, 119991; Shatura, 140700
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