Email this article Selective cytotoxic Pt(II) complexes of phenanthroline derivatives
- Authors: Abedi A.1
-
Affiliations:
- Department of Chemistry, North Tehran Branch
- Issue: Vol 62, No 12 (2017)
- Pages: 1595-1599
- Section: Coordination Compounds
- URL: https://journal-vniispk.ru/0036-0236/article/view/168224
- DOI: https://doi.org/10.1134/S0036023617120026
- ID: 168224
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Abstract
A new dichloroplatinum(II) complex with 5-methyl-1,10-phenanthroline (1) has been obtained and characterized by X-ray diffraction. MTT assay was used for in vitro cytotoxicity evaluation of this complex, along with a similar complex with 4,7-diphenyl-1,10-phenanthroline (2) against normal and cancerous cell lines. Interestingly, the IC50 values of the new complexes were higher for normal cells and in the case of complex 2, lower against all studied human cancer cells, in comparison with cisplatin.
About the authors
Anita Abedi
Department of Chemistry, North Tehran Branch
Author for correspondence.
Email: a_abedi@iau-tnb.ac.ir
Iran, Islamic Republic of, Tehran, 19585-936
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