Email this article Solubilization of Biologically Active Heterocyclic Compounds by Biocompatible Microemulsions
- Authors: Mirgorodskaya A.B.1, Kushnazarova R.A.1, Zhukova N.A.1, Mamedov V.A.1,2, Zakharova L.Y.1,2, Sinyashin O.G.1,2
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
- Kazan National Research Technological University
- Issue: Vol 92, No 12 (2018)
- Pages: 2588-2592
- Section: Biophysical Chemistry
- URL: https://journal-vniispk.ru/0036-0244/article/view/170270
- DOI: https://doi.org/10.1134/S0036024418120312
- ID: 170270
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Abstract
Microemulsions based on biocompatible components with high water content are applied to increase the solubility of medicinal drugs of the heterocyclic series indomethacin and 1-[5-(4-chlorophenyl)-3-phenylpyrrole-2-yl]benzimidazole-2(3H)-one (PBI). The solubilizing capacity is characterized quantitatively via spectrophotometry. It is shown that four-component microemulsion water/oleic acid/Tween 80/ethanol increases the limits of indomethacin solubility by more than two orders of magnitude, and that of PBI by more than three orders relative to water.
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About the authors
A. B. Mirgorodskaya
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences
Author for correspondence.
Email: mirgoralla@mail.ru
Russian Federation, Kazan, 420088
R. A. Kushnazarova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences
Email: mirgoralla@mail.ru
Russian Federation, Kazan, 420088
N. A. Zhukova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences
Email: mirgoralla@mail.ru
Russian Federation, Kazan, 420088
V. A. Mamedov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences; Kazan National Research Technological University
Email: mirgoralla@mail.ru
Russian Federation, Kazan, 420088; Kazan, 420015
L. Ya. Zakharova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences; Kazan National Research Technological University
Email: mirgoralla@mail.ru
Russian Federation, Kazan, 420088; Kazan, 420015
O. G. Sinyashin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences; Kazan National Research Technological University
Email: mirgoralla@mail.ru
Russian Federation, Kazan, 420088; Kazan, 420015
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