Email this article Adipokines and the cardiorespiratory system in young patients with type 1 diabetes mellitus
- Authors: Vengrzhinovskaya O.I.1, Bondarenko I.Z.1, Shatskaya O.A.1, Nikankina l.V.1, Kalashnikov V.Y.1, Shestakova M.V.1, Mokrysheva N.G.1
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Affiliations:
- National Medical Research Center for Endocrinology
- Issue: Vol 94, No 10 (2022)
- Pages: 1143-1148
- Section: Original articles
- URL: https://journal-vniispk.ru/0040-3660/article/view/108271
- DOI: https://doi.org/10.26442/00403660.2022.10.201889
- ID: 108271
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Abstract
Early screening of complications of diabetes mellitus (DM) is one of the priorities for public health. Most patients with type 1 diabetes mellitus (T1DM) are patients of working age. New strategies for the primary prevention of cardiovascular disease (CVD) are needed to prevent their early disability.
Aim. To assess the predictive value of adipokines in relation to a personalized approach to the need for an in-depth examination of young patients with T1DM.
Materials and methods. The study included 98 patients without CVD: 70 patients with T1DM (mean age 26.4±8.1 years) and 28 patients without DM (mean age 27±9 years). All patients underwent a general clinical examination, the levels of adipokines were determined, ergospirometry, echocardiography, and bioimpedancemetry were performed.
Results. Changes in the cardiorespiratory system in patients with T1DM were revealed, in comparison with persons without T1DM: anaerobic threshold was reached faster (p=0.001), maximum oxygen consumption was lower (p=0.048), metabolic equivalent was reduced (p=0.0001). Signs of myocardial remodeling were found in the T1DM group: there was an increase in the relative wall thickness (p=0.001), the posterior wall of the left ventricle (p=0.001), myocardial mass index (p=0.049), in comparison with persons without T1DM. Changes in the adipokines system were revealed: higher levels of resistin (p=0.002) and visfatin (p=0.001), lower level of adiponectin (p=0.040) in T1DM. A positive correlation was found between posterior wall of the left ventricle and visfatin (p=0.014) and a negative relationship between adiponectin and relative wall thickness (p=0.018) in T1DM.
Conclusion. In T1DM, even at a young age, there are multifactorial changes in the heart, which can be detected even at the preclinical stage. The data obtained can be used to identify groups of patients at high risk of developing dangerous CVD in T1DM, which can form the basis for determining the timing of the start of preventive therapy.
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##article.viewOnOriginalSite##About the authors
Oksana I. Vengrzhinovskaya
National Medical Research Center for Endocrinology
Author for correspondence.
Email: ksuyhap03@mail.ru
ORCID iD: 0000-0003-3370-8630
врач-эндокринолог
Russian Federation, MoscowIrina Z. Bondarenko
National Medical Research Center for Endocrinology
Email: iz_bondarenko@mail.ru
ORCID iD: 0000-0002-5178-6029
д-р мед. наук, врач-кардиолог, гл. науч. сотр.
Russian Federation, MoscowOlga A. Shatskaya
National Medical Research Center for Endocrinology
Email: shatskaya@bk.ru
ORCID iD: 0000-0003-1831-8052
канд. мед. наук, врач-эндокринолог, вед. науч. сотр.
Russian Federation, Moscowlarisa V. Nikankina
National Medical Research Center for Endocrinology
Email: larisa.nikankina@yandex.ru
ORCID iD: 0000-0002-3199-4998
канд. мед. наук, врач клинической лабораторной диагностики, и.о. зав. клинико-диагностической лаб.
Russian Federation, MoscowViktor Y. Kalashnikov
National Medical Research Center for Endocrinology
Email: victor9368@gmail.com
ORCID iD: 0000-0001-5573-0754
чл.-кор. РАН, д-р мед. наук, проф., зав. отд. кардиологии и сосудистой хирургии
Russian Federation, MoscowMarina V. Shestakova
National Medical Research Center for Endocrinology
Email: Shestakova.Marina@endocrincentr.ru
ORCID iD: 0000-0003-3893-9972
акад. РАН, д-р мед. наук, проф., зав. каф. диабетологии и диетологии, дир. Института диабета, зам. дир.
Russian Federation, MoscowNatalia G. Mokrysheva
National Medical Research Center for Endocrinology
Email: mokrisheva.natalia@endocrincentr.ru
ORCID iD: 0000-0002-9717-9742
чл.-кор. РАН, д-р мед. наук, проф., врач-эндокринолог, дир.
Russian Federation, MoscowReferences
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