Email this article Clinical and prognostic implications of gastrointestinal tract lesions in systemic vascular purpuras
- Authors: Mukhin NA1, Gulyaev SV1, Krivosheev ОG1, Semenkova ЕN1, Kogan EA2, Okhotnikova NL1, Zavodnov VY.1, Gmoshinsky IV2, Mazo VK2, Grane R3, Bjarnason I3
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Affiliations:
- ММА им. И. М. Сеченова
- ГУ НИИ питания РАМН
- Королевский медицинский колледж
- Issue: Vol 78, No 2 (2003)
- Pages: 50-54
- Section: Editorial article
- URL: https://journal-vniispk.ru/0040-3660/article/view/29315
- ID: 29315
Cite item
Abstract
Material and methods. Incidence, clinical picture, complications of abdominal syndrome, its relations with principal extraintestinal manifestations of SVP were studied in 125 SVP patients. Absorption and barrier functions of the small intestine, their correlations with clinical activity of the disease were investigated in 32 SVP patients with no clinical signs of intestinal affection. Computer-assisted morphometry of duodenal mucosa biopsies was conducted and the results were compared to those of intestinal permiability and clinical activity of SVP.
Results. Negative correlation was found between the occurrence of abdominal syndrome and the patients' age. The gastrointestinal tract suffered more frequently in men. 21% patients had abdominal complications, association of abdominal syndrome with higher frequency of glomerulonephritis. In the absence of abdominal symptoms, the barrier function of the small intestine for protein macromolecules was impaired. This correlated with exacerbations of skin purpura. Increased intestinal permeability and activity of skin purpura correlated with severity of inflammation in the duodenal mucosa. Conclusion. Abdominal syndrome in SVP is an unfavourable prognostic factor indicating possible severe complications and high risk of glomerulonephritis. Subclinical intestinal involvement presenting as barrier dysfunction may contribute to aggravation of skin vasculitis.
About the authors
N A Mukhin
ММА им. И. М. СеченоваММА им. И. М. Сеченова
S V Gulyaev
ММА им. И. М. СеченоваММА им. И. М. Сеченова
О G Krivosheev
ММА им. И. М. СеченоваММА им. И. М. Сеченова
Е N Semenkova
ММА им. И. М. СеченоваММА им. И. М. Сеченова
E A Kogan
ГУ НИИ питания РАМНЛаборатория физиологии и биохимии пищеварения; ГУ НИИ питания РАМН
N L Okhotnikova
ММА им. И. М. СеченоваММА им. И. М. Сеченова
V Ya Zavodnov
ММА им. И. М. СеченоваММА им. И. М. Сеченова
I V Gmoshinsky
ГУ НИИ питания РАМНЛаборатория физиологии и биохимии пищеварения; ГУ НИИ питания РАМН
V K Mazo
ГУ НИИ питания РАМНЛаборатория физиологии и биохимии пищеварения; ГУ НИИ питания РАМН
R Grane
Королевский медицинский колледжЛондон; Королевский медицинский колледж
I Bjarnason
Королевский медицинский колледжЛондон; Королевский медицинский колледж
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